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Vol 17, No 4 (2020)
Review paper
Published online: 2020-09-18

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Analysis of neuropsychiatric disorders caused by infection Tropheryma whipplei

Roksana Duszkiewicz1, Justyna Gacek21, Filip Hajdrowski1, Agnieszka Greń1, Krzysztof Silski1, Miłosz Gołyszny1, Tomasz Ludyga1
Psychiatria 2020;17(4):224-228.


Whipple’s disease is a rare, chronic systemic infection caused by gram-positive Tropheryma whipplei actinobacterium.
So far, the reasons for the Tropheryma whipplei infection have not been explained. Clinical symptoms are non-specific
and may suggest other diseases, mainly gastrointestinal disease. Nervous system symptoms such as personality disorders,
behavioral disorders, depressive symptoms and disturbances of consciousness are also observed.
The aim of the study is to collect information on neuropsychological disorders found in Whipple’s disease.
Central nervous system (CNS) involvement can take place in three cases: classic form, in the relapse of previously treated
classic form (with changes in the digestive system) and in isolated CNS infection (without evidence of gastrointestinal
involvement by T. whipplei). Neurological disorders resulting from CNS involvement are variable and may be similar to
other diseases of the nervous system. Treatment is difficult due to the long-term course of the disease and non-specificity
of its symptoms, which is why the problem is the selection of effective pharmacotherapy. Untreated disease results
in worsening neuropsychological disorders. Pharmacotherapy involves the use of antibiotics. The use of antibacterial
therapy reduces the risk of recurrence of clinical symptoms.

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