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Vol 17, No 1 (2020)
Review paper
Published online: 2020-03-05

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Aripiprazole: monotherapy?

Agata Szulc
Psychiatria 2020;17(1):29-35.


Polypharmacy, meaning combining two or more antipsychotic agents, is frequently used not only in Poland, but across the world. It is estimated, that even 2/3 of patients receive polypharmacy. It may be justified in the acute phase of illness and/or in the treatment resistant patients, or during the switching period from one drug to another. However, it should not be treated as a routine practice because of the increased risk of the adverse events. The analysis of the long-term adverse events of polypharmacy is essential, since those events may increase over the time. Amongst them the weight increase, glucose intolerance, hyperlipidemia, extrapyramidal symptoms, hyperprolactinemia, OTc prolongation and sedation are observed. Aripiprazole is one of the atypical or II generation antipsychotics known for several years. Many clinical trials and everyday practice confirm its clinical efficacy in schizophrenia and bipolar disorder. It is frequently used in the combination with the other antipsychotics. This paper reviews data about aripiprazole application in monotherapy, which should become a routine practice in the mental diseases treatment.

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