open access

Vol 15, No 2 (2018)
Review paper
Published online: 2018-06-27
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Intestinal flora and the pathophysiology of depression and anxiety disorders — current state of the art and future perspectives

Paweł Jan Liśkiewicz, Justyna Pełka-Wysiecka, Michał Wroński, Agata Bąba-Kubiś, Jerzy Samochowiec
Psychiatria 2018;15(2):70-76.

open access

Vol 15, No 2 (2018)
Prace poglądowe - nadesłane
Published online: 2018-06-27

Abstract

Depressive and anxiety disorders are a significant diagnostic and therapeutic problem, as they cause serious health, social
and financial implications. Due to their disabling effect on life and functioning, new and effective treatment directions
are needed. In recent years, researchers have been looking for alternative pathomechanisms of depression and anxiety,
which has triggered interest in exploraton of neuroimmune, endocrine and microbiological phenomena and processes.
The relationship between symptoms of mental disorders and functioning of the intestinal flora have been intensively
investigated. Most studies involved analyses conducted on animal models. So far, the results have been promising, but
they are still insufficient to elaborate specific standards of diagnostic and therapeutic procedures. The authors of this
review hope that they will help the reader to comprehend the discussed pathomechanisms and encourage their own,
original research.

Abstract

Depressive and anxiety disorders are a significant diagnostic and therapeutic problem, as they cause serious health, social
and financial implications. Due to their disabling effect on life and functioning, new and effective treatment directions
are needed. In recent years, researchers have been looking for alternative pathomechanisms of depression and anxiety,
which has triggered interest in exploraton of neuroimmune, endocrine and microbiological phenomena and processes.
The relationship between symptoms of mental disorders and functioning of the intestinal flora have been intensively
investigated. Most studies involved analyses conducted on animal models. So far, the results have been promising, but
they are still insufficient to elaborate specific standards of diagnostic and therapeutic procedures. The authors of this
review hope that they will help the reader to comprehend the discussed pathomechanisms and encourage their own,
original research.

Get Citation

Keywords

microbiota, microbiome, affective disorders, depression, depressive disorders, anxiety disorders, inflammation, probiotics

About this article
Title

Intestinal flora and the pathophysiology of depression and anxiety disorders — current state of the art and future perspectives

Journal

Psychiatria (Psychiatry)

Issue

Vol 15, No 2 (2018)

Article type

Review paper

Pages

70-76

Published online

2018-06-27

Bibliographic record

Psychiatria 2018;15(2):70-76.

Keywords

microbiota
microbiome
affective disorders
depression
depressive disorders
anxiety disorders
inflammation
probiotics

Authors

Paweł Jan Liśkiewicz
Justyna Pełka-Wysiecka
Michał Wroński
Agata Bąba-Kubiś
Jerzy Samochowiec

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