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Intestinal flora and the pathophysiology of depression and anxiety disorders — current state of the art and future perspectives
Affiliations- Katedra i Klinika Psychiatrii, Pomorski Uniwersytet Medyczny w Szczecinie, Szczecin
open access
Abstract
Depressive and anxiety disorders are a significant diagnostic and therapeutic problem, as they cause serious health, social
and financial implications. Due to their disabling effect on life and functioning, new and effective treatment directions
are needed. In recent years, researchers have been looking for alternative pathomechanisms of depression and anxiety,
which has triggered interest in exploraton of neuroimmune, endocrine and microbiological phenomena and processes.
The relationship between symptoms of mental disorders and functioning of the intestinal flora have been intensively
investigated. Most studies involved analyses conducted on animal models. So far, the results have been promising, but
they are still insufficient to elaborate specific standards of diagnostic and therapeutic procedures. The authors of this
review hope that they will help the reader to comprehend the discussed pathomechanisms and encourage their own,
original research.
Abstract
Depressive and anxiety disorders are a significant diagnostic and therapeutic problem, as they cause serious health, social
and financial implications. Due to their disabling effect on life and functioning, new and effective treatment directions
are needed. In recent years, researchers have been looking for alternative pathomechanisms of depression and anxiety,
which has triggered interest in exploraton of neuroimmune, endocrine and microbiological phenomena and processes.
The relationship between symptoms of mental disorders and functioning of the intestinal flora have been intensively
investigated. Most studies involved analyses conducted on animal models. So far, the results have been promising, but
they are still insufficient to elaborate specific standards of diagnostic and therapeutic procedures. The authors of this
review hope that they will help the reader to comprehend the discussed pathomechanisms and encourage their own,
original research.
Keywords
microbiota, microbiome, affective disorders, depression, depressive disorders, anxiety disorders, inflammation, probiotics
About this articleTitle
Intestinal flora and the pathophysiology of depression and anxiety disorders — current state of the art and future perspectives
Journal
Issue
Article type
Review paper
Pages
70-76
Published online
2018-06-27
Page views
2675
Article views/downloads
8427
Bibliographic record
Psychiatria 2018;15(2):70-76.
Keywords
microbiota
microbiome
affective disorders
depression
depressive disorders
anxiety disorders
inflammation
probiotics
Authors
Paweł Jan Liśkiewicz
Justyna Pełka-Wysiecka
Michał Wroński
Agata Bąba-Kubiś
Jerzy Samochowiec
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