Tom 15, Nr 1 (2018)
Opis przypadku
Opublikowany online: 2018-03-28
Wyświetlenia strony
2193
Wyświetlenia/pobrania artykułu
43971
Uzależnienie od ekstremalnie dużych dawek zolpidemu — opis przypadku i przegląd piśmiennictwa
Psychiatria 2018;15(1):13-25.
Streszczenie
W pracy przedstawiono przypadek lekarki uzależnionej od ekstremalnie dużej dawki zolpidemu, nadużywającej także kodeiny i kofeiny, która z powodu tych problemów oraz powikłań leczenia zespołu abstynencyjnego była długotrwale hospitalizowana psychiatrycznie. Omówiono szczególne problemy kliniczne i terapeutyczne wiążące się uzależnieniem od wysokich dawek zolpidemu występujące w trakcie odstawiania leku. Ponadto zaprezentowane współczesne dane wskazujące na wiele możliwych poważnych skutków nadużywania tego leku, których lekarze przepisujący go powinni być świadomi.
Słowa kluczowe: zolpidemuzależenieniezespół abstynencyjnypowikłania
Referencje
- Fitzgerald AC, Wright BT, Heldt SA. The behavioral pharmacology of zolpidem: evidence for the functional significance of α1-containing GABA(A) receptors. Psychopharmacology (Berl). 2014; 231(9): 1865–1896.
- Jembrek MJ, Vlainić J, Šuran J. Zolpidem withdrawal induced uncoupling of GABA(A) receptors in vitro associated with altered GABA(A) receptor subunit mRNA expression. Acta Neurobiol Exp (Wars). 2015; 75(2): 160–171.
- Hoffmann F, Pfannkuche M, Glaeske G. [High usage of zolpidem and zopiclone. Cross-sectional study using claims data]. Nervenarzt. 2008; 79(1): 67–72.
- Wainstein L, Victorri-Vigneau C, Sébille V, et al. Pharmacoepidemiological characterization of psychotropic drugs consumption using a latent class analysis. Int Clin Psychopharmacol. 2011; 26(1): 54–62.
- Gołda A, Dymek J, Dziwisz K, et al. Legalni użytkownicy nierefundowanych leków psychotropowych w sce – badanie pilotażowe. Farm Pol. 2014; 70(12): 665–674.
- Victorri-Vigneau C, Dailly E, Veyrac G, et al. Evidence of zolpidem abuse and dependence: results of the French Centre for Evaluation and Information on Pharmacodependence (CEIP) network survey. Br J Clin Pharmacol. 2007; 64(2): 198–209.
- Liappas IA, Malitas PN, Dimopoulos NP, et al. Zolpidem dependence case series: possible neurobiological mechanisms and clinical management. J Psychopharmacol. 2003; 17(1): 131–135.
- Jamroży A, Habrat B, Basińska-Starzycka A. Uzależnienie od niebenzodiazepinowych leków nasennych: opis dziesięciu przypadków. Alkoholizm i Narkomania. 2009; 22(1): 87–105.
- Cubała WJ. Czynniki wpływające na ryzyko wystąpienia działań niepożądanych w trakcie leczenia zolpidemem. Psychiatria. 2007; 4(3): 124–127.
- Cubała WJ, Landowski J, Wichowicz HM. Zolpidem abuse, dependence and withdrawal syndrome: sex as susceptibility factor for adverse effects. Br J Clin Pharmacol. 2008; 65(3): 444–445.
- Olubodun JO, Ochs HR, Trüten V, et al. Zolpidem pharmacokinetic properties in young females: influence of smoking and oral contraceptive use. J Clin Pharmacol. 2002; 42(10): 1142–1146.
- Hajak G, Müller WE, Wittchen HU, et al. Abuse and dependence potential for the non-benzodiazepine hypnotics zolpidem and zopiclone: a review of case reports and epidemiological data. Addiction. 2003; 98(10): 1371–1378.
- Shukla L, Bokka S, Shukla T, et al. Benzodiazepine and "Z-Drug" Dependence: Data From a Tertiary Care Center. Prim Care Companion CNS Disord. 2017; 19(1).
- McBeth BD, McNamara RM, Ankel FK, et al. Modafinil and zolpidem use by emergency medicine residents. Acad Emerg Med. 2009; 16(12): 1311–1317.
- Sanna E, Busonero F, Talani G, et al. Comparison of the effects of zaleplon, zolpidem, and triazolam at various GABA(A) receptor subtypes. Eur J Pharmacol. 2002; 451(2): 103–110.
- Kralic JE, O'Buckley TK, Khisti RT, et al. GABA(A) receptor alpha-1 subunit deletion alters receptor subtype assembly, pharmacological and behavioral responses to benzodiazepines and zolpidem. Neuropharmacology. 2002; 43(4): 685–694.
- Chattopadhyay AC, Shukla L, Kandasamy A, et al. High-dose zolpidem dependence - Psychostimulant effects? A case report and literature review. Ind Psychiatry J. 2016; 25(2): 222–224.
- Boulanger-Rostowsky L, Fayet H, Benmoussa N, et al. [Dependence on zolpidem: a report of two cases]. Encephale. 2004; 30(2): 153–155.
- Huang MC, Lin HY, Chen CH. Dependence on zolpidem. Psychiatry Clin Neurosci. 2007; 61(2): 207–208.
- Cubała WJ, Wichowicz HM. Dependence on zolpidem: is pharmacokinetics important? Psychiatry Clin Neurosci. 2008; 62(1): 127.
- Zhou SF. Drugs behave as substrates, inhibitors and inducers of human cytochrome P450 3A4. Curr Drug Metab. 2008; 9(4): 310–322.
- Sun Yu, Lin CC, Lu CJ, et al. Association Between Zolpidem and Suicide: A Nationwide Population-Based Case-Control Study. Mayo Clin Proc. 2016; 91(3): 308–315.
- Huang WS, Tsai CH, Lin CC, et al. Relationship between zolpidem use and stroke risk: a Taiwanese population-based case-control study. J Clin Psychiatry. 2013; 74(5): e433–e438.
- Huang HC, Tsai CH, Muo CH, et al. Risk of Parkinson's disease following zolpidem use: a retrospective, population-based cohort study. J Clin Psychiatry. 2015; 76(1): e104–e110.
- Lai SW. Risks and benefits of zolpidem use in Taiwan: a narrative review. Biomedicine (Taipei). 2016; 6(2): 8.
- Kao CH, Sun LM, Liang JA. Relationship of zolpidem and cancer risk: a Taiwanese population-based cohort study. Mayo Clin Proc. 2012; 87(5): 430–436.
- Lai MM, Lin CC, Lin CC, et al. Long-term use of zolpidem increases the risk of major injury: a population-based cohort study. Mayo Clin Proc. 2014; 89(5): 589–594.
- Ho YH, Chang YC, Huang WC, et al. Association between zolpidem use and glaucoma risk: a Taiwanese population-based case-control study. J Epidemiol. 2014 [Epub ahead of print]; 25(1)–19.
- Orriols L, Philip P, Moore N, et al. CESIR Research Group. Benzodiazepine-like hypnotics and the associated risk of road traffic accidents. Clin Pharmacol Ther. 2011; 89(4): 595–601.
- Wang LH, Lin HC, Lin CC, et al. Increased risk of adverse pregnancy outcomes in women receiving zolpidem during pregnancy. Clin Pharmacol Ther. 2010; 88(3): 369–374.
- Lai SW, Lin CL, Liao KF. Increased relative risk of acute pancreatitis in zolpidem users. Psychopharmacology (Berl). 2015; 232(12): 2043–2048.
- Chen SC, Chen HC, Liao SC, et al. Detoxification of high-dose zolpidem using cross-titration with an adequate equivalent dose of diazepam. Gen Hosp Psychiatry. 2012; 34(2): 210.e5–210.e7.
- Fernandes WH, Pereira YD, O' Tereza S. A case of Zolpidem dependence successfully detoxified with gabapentin. Indian J Psychiatry. 2013; 55(3): 290–292.
- Oulis P, Nakkas G, Masdrakis VG. Pregabalin in zolpidem dependence and withdrawal. Clin Neuropharmacol. 2011; 34(2): 90–91.
- Quaglio G, Faccini M, Vigneau CV, et al. Megadose bromazepam and zolpidem dependence: two case reports of treatment with flumazenil and valproate. Subst Abus. 2012; 33(2): 195–198.
- Quaglio G, Lugoboni F, Fornasiero A, et al. Dependence on zolpidem: two case reports of detoxification with flumazenil infusion. Int Clin Psychopharmacol. 2005; 20(5): 285–287.
- Jana AK, Arora M, Khess CRJ, et al. A case of zolpidem dependence successfully detoxified with clonazepam. Am J Addict. 2008; 17(4): 343–344.
- Liappas IA, Malitas PN, Dimopoulos NP, et al. Three cases of zolpidem dependence treated with fluoxetine: the serotonin hypothesis. World J Biol Psychiatry. 2003; 4(2): 93–96.
- Mariani JJ, Levin FR. Quetiapine treatment of zolpidem dependence. Am J Addict. 2007; 16(5): 426.
- Lin SK. Rapid detoxification of benzodiazepine or Z-drugs dependence using acetylcholinesterase inhibitors. Med Hypotheses. 2014; 83(1): 108–110.
- Aragona M. Abuse, dependence, and epileptic seizures after zolpidem withdrawal: review and case report. Clin Neuropharmacol. 2000; 23(5): 281–283.
- Tripodianakis J, Potagas C, Papageorgiou P, et al. Zolpidem-related epileptic seizures: a case report. Eur Psychiatry. 2003; 18(3): 140–141.
- Cubała WJ, Landowski J. Seizure following sudden zolpidem withdrawal. Prog Neuropsychopharmacol Biol Psychiatry. 2007; 31(2): 539–540.
- Liappas IA, Papageorgiou CC, Rabavilas AD. Abnormal auditory N400 in a case of zolpidem dependence, during a working memory test. Eur Psychiatry. 2006; 21(2): 135–137.
- Stanton J, Randal P. Developing a psychiatrist-patient relationship when both people are doctors: a qualitative study. BMJ Open. 2016; 6(5): e010216.
