open access

Vol 13, No 1 (2016)
Case report
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Pregabalin — case study in the framework of its mode of action and practical use guidelines

Sławomir Murawiec
Psychiatria 2016;13(1):17-24.

open access

Vol 13, No 1 (2016)
Prace kazuistyczne

Abstract

Pregabalin is anxiolytic agent, approved in the for the treatment of generalized anxiety disorder (GAD) in adults, with efficacy and tolerability demonstrated in numerous studies. The course of long term (15 months) study of male patient with GAD treated with pregabalin 225 mg was described and in the report data obtained from case study were systematically paired with data from scientific publications. Symptoms of GAD were presented as well as improvement of those symptoms in the course of treatment in patient subjective experience as regards anxiety symptoms and everyday functioning. The pharmacological mode of action of pregabalin is based on modulation of voltage-dependant calcium channels resulting in a reduction in neurotransmission in excited neurons. Pregabalin was in this case safe in the treatment of patient with non-alcoholic fatty liver disease (NAFLD) as it is not metabolized in liver. Special attention was focused on impact of pregabalin on anticipation of an emotional stimulus. One study showed that pregabalin attenuates amygdala and insula activation but increases medial PFC activation in this paradigm. Pregabalin shares some similarity to SSRIs and benzodiazepines in attenuating anger and fear during emotional face processing but has a slightly different effect on brain activation as it relates to anticipation and emotional face processing, which may account for its unique characteristic in the treatment of anxiety disorders. Pregabalin is effective in treatment of patients with moderate to severe GAD, it has faster onset of action than SSRIs and SNRIs and broad spectrum activity against both psychic and somatic symptoms of GAD.

Abstract

Pregabalin is anxiolytic agent, approved in the for the treatment of generalized anxiety disorder (GAD) in adults, with efficacy and tolerability demonstrated in numerous studies. The course of long term (15 months) study of male patient with GAD treated with pregabalin 225 mg was described and in the report data obtained from case study were systematically paired with data from scientific publications. Symptoms of GAD were presented as well as improvement of those symptoms in the course of treatment in patient subjective experience as regards anxiety symptoms and everyday functioning. The pharmacological mode of action of pregabalin is based on modulation of voltage-dependant calcium channels resulting in a reduction in neurotransmission in excited neurons. Pregabalin was in this case safe in the treatment of patient with non-alcoholic fatty liver disease (NAFLD) as it is not metabolized in liver. Special attention was focused on impact of pregabalin on anticipation of an emotional stimulus. One study showed that pregabalin attenuates amygdala and insula activation but increases medial PFC activation in this paradigm. Pregabalin shares some similarity to SSRIs and benzodiazepines in attenuating anger and fear during emotional face processing but has a slightly different effect on brain activation as it relates to anticipation and emotional face processing, which may account for its unique characteristic in the treatment of anxiety disorders. Pregabalin is effective in treatment of patients with moderate to severe GAD, it has faster onset of action than SSRIs and SNRIs and broad spectrum activity against both psychic and somatic symptoms of GAD.

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Keywords

pregabalin, generalized anxiety disorder, case study

About this article
Title

Pregabalin — case study in the framework of its mode of action and practical use guidelines

Journal

Psychiatria (Psychiatry)

Issue

Vol 13, No 1 (2016)

Article type

Case report

Pages

17-24

Bibliographic record

Psychiatria 2016;13(1):17-24.

Keywords

pregabalin
generalized anxiety disorder
case study

Authors

Sławomir Murawiec

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