open access

Vol 10, No 2 (2013)
Review paper
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Vilazodone — a new multifunctional antidepressant

Adam Wysokiński, Iwona Kłoszewska
Psychiatria 2013;10(2):72-75.

open access

Vol 10, No 2 (2013)
Prace poglądowe - nadesłane

Abstract

Vilazodone is a new multifunctional antidepressive agent. Its mechanism of action includes inhibition of serotonin reuptake and partial agonism at the 5-HT1A serotonergic autoreceptor. Because of this, it increases serotonin concentration in the synaptic gap more than classic serotonin reuptake inhibitors. Slow dose titration up to the maximum and therapeutic dose of 40 mg/day is required. Vilazodone has to be taken with food, its blood level may be reduced by 50% otherwise. It is metabolized in the liver, mainly by CYP3A4. Two randomized, double blind clinical trials demonstrated its efficacy against placebo in short-term (8 weeks) treatment of major depression. Long-term efficacy was evaluated only in an open study. Safety profile does not differ from the one observed for other serotonergic antidepressants. The most commonly observed adverse events are nausea, diarrhea, and headaches. Currently available data do not indicate that vilazodone is superior to other antidepressants.

Abstract

Vilazodone is a new multifunctional antidepressive agent. Its mechanism of action includes inhibition of serotonin reuptake and partial agonism at the 5-HT1A serotonergic autoreceptor. Because of this, it increases serotonin concentration in the synaptic gap more than classic serotonin reuptake inhibitors. Slow dose titration up to the maximum and therapeutic dose of 40 mg/day is required. Vilazodone has to be taken with food, its blood level may be reduced by 50% otherwise. It is metabolized in the liver, mainly by CYP3A4. Two randomized, double blind clinical trials demonstrated its efficacy against placebo in short-term (8 weeks) treatment of major depression. Long-term efficacy was evaluated only in an open study. Safety profile does not differ from the one observed for other serotonergic antidepressants. The most commonly observed adverse events are nausea, diarrhea, and headaches. Currently available data do not indicate that vilazodone is superior to other antidepressants.

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Keywords

depressive disorder, vilazodone, antidepressive agents

About this article
Title

Vilazodone — a new multifunctional antidepressant

Journal

Psychiatria (Psychiatry)

Issue

Vol 10, No 2 (2013)

Article type

Review paper

Pages

72-75

Bibliographic record

Psychiatria 2013;10(2):72-75.

Keywords

depressive disorder
vilazodone
antidepressive agents

Authors

Adam Wysokiński
Iwona Kłoszewska

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