Vol 1, No 1 (2004)
Prace przeglądowe - tłumaczenia
Published online: 2004-04-26
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Effeciveness of pindolol plus serotonin uptake inhibitors in depression: a meta-analysis of early and late outcomes from randomized controlled trials.

Javier Ballesteros, Luis F. Callado
Psychiatria 2004;1(1):51-62.
Vol 1, No 1 (2004)
Prace przeglądowe - tłumaczenia
Published online: 2004-04-26

Abstract

Background: Contradictory results on the efficacy of pindolol associated with selective serotonin reuptake inhibitors (SSRIs) in depressive illness have been published and no former review has produced an overall figure of its efficacy. This study aims to review the efficacy and tolerability of pindolol plus SSRIs in depressive illness.
Material and methods: A meta-analysis of randomised controlled trials (RCTs) comparing pindolol plus SSRIs with placebo plus SSRIs.
Results:
Nine RCTs met inclusion criteria. Outcome favoured pindolol at 2 weeks time (N = 5; OR = 2.8; 95% CI 1.4–5.7), but not at four to 6 weeks (N = 7; OR = 1.4; 95% CI 0.8–2.7). Results for early outcome studies were robust to sensitivity analysis. Nineteen more studies, averaging null results, would be needed to change the overall probability (P = 0.0001) to a non-significant figure.
Conclusions: Pindolol seems to hasten the response to SSRIs in depression with a timing window circumscribed to the first weeks of treatment.

Abstract

Background: Contradictory results on the efficacy of pindolol associated with selective serotonin reuptake inhibitors (SSRIs) in depressive illness have been published and no former review has produced an overall figure of its efficacy. This study aims to review the efficacy and tolerability of pindolol plus SSRIs in depressive illness.
Material and methods: A meta-analysis of randomised controlled trials (RCTs) comparing pindolol plus SSRIs with placebo plus SSRIs.
Results:
Nine RCTs met inclusion criteria. Outcome favoured pindolol at 2 weeks time (N = 5; OR = 2.8; 95% CI 1.4–5.7), but not at four to 6 weeks (N = 7; OR = 1.4; 95% CI 0.8–2.7). Results for early outcome studies were robust to sensitivity analysis. Nineteen more studies, averaging null results, would be needed to change the overall probability (P = 0.0001) to a non-significant figure.
Conclusions: Pindolol seems to hasten the response to SSRIs in depression with a timing window circumscribed to the first weeks of treatment.
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Keywords

depression; effectiveness; meta-analysis; outcome; pindolol; SSRI

About this article
Title

Effeciveness of pindolol plus serotonin uptake inhibitors in depression: a meta-analysis of early and late outcomes from randomized controlled trials.

Journal

Psychiatria (Psychiatry)

Issue

Vol 1, No 1 (2004)

Pages

51-62

Published online

2004-04-26

Bibliographic record

Psychiatria 2004;1(1):51-62.

Keywords

depression
effectiveness
meta-analysis
outcome
pindolol
SSRI

Authors

Javier Ballesteros
Luis F. Callado

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