Skuteczność pindololu i inhibitorów wychwytu serotoniny w depresji: metaanaliza wczesnych i późnych wyników
Streszczenie
Material and methods: A meta-analysis of randomised controlled trials (RCTs) comparing pindolol plus SSRIs with placebo plus SSRIs.
Results: Nine RCTs met inclusion criteria. Outcome favoured pindolol at 2 weeks time (N = 5; OR = 2.8; 95% CI 1.4–5.7), but not at four to 6 weeks (N = 7; OR = 1.4; 95% CI 0.8–2.7). Results for early outcome studies were robust to sensitivity analysis. Nineteen more studies, averaging null results, would be needed to change the overall probability (P = 0.0001) to a non-significant figure.
Conclusions: Pindolol seems to hasten the response to SSRIs in depression with a timing window circumscribed to the first weeks of treatment.
Streszczenie
Material and methods: A meta-analysis of randomised controlled trials (RCTs) comparing pindolol plus SSRIs with placebo plus SSRIs.
Results: Nine RCTs met inclusion criteria. Outcome favoured pindolol at 2 weeks time (N = 5; OR = 2.8; 95% CI 1.4–5.7), but not at four to 6 weeks (N = 7; OR = 1.4; 95% CI 0.8–2.7). Results for early outcome studies were robust to sensitivity analysis. Nineteen more studies, averaging null results, would be needed to change the overall probability (P = 0.0001) to a non-significant figure.
Conclusions: Pindolol seems to hasten the response to SSRIs in depression with a timing window circumscribed to the first weeks of treatment.
Słowa kluczowe
depresja; skuteczność; metaanaliza; wyniki; pindolol; SSRI
Tytuł
Skuteczność pindololu i inhibitorów wychwytu serotoniny w depresji: metaanaliza wczesnych i późnych wyników
Czasopismo
Numer
Strony
51-62
Opublikowany online
2004-04-26
Wyświetlenia strony
867
Rekord bibliograficzny
Psychiatria 2004;1(1):51-62.
Słowa kluczowe
depresja
skuteczność
metaanaliza
wyniki
pindolol
SSRI
Autorzy
Javier Ballesteros
Luis F. Callado