open access

Vol 2, No 1 (2005)
Review paper
Published online: 2004-12-08
Get Citation

Addiction pathogenesis in genetic research

Agnieszka Samochowiec, Agnieszka Mordasewicz, Georg Arentowicz, Jerzy Samochowiec
Psychiatria 2005;2(1):9-18.

open access

Vol 2, No 1 (2005)
Prace poglądowe - nadesłane
Published online: 2004-12-08

Abstract

The familial occurence of alcoholism has been known for many years. Approximatly 50–60% of individual differences in risk for alcoholism is genetic, and this proportion is approximately equal in man and woman. The goal of this article is to review the current status in the search for “candidate gens” for alcohol dependence. There are three basic approaches to identifying important genes. First, one can target genes based on their presumed importance in influencing alcohol sensitivity. The targeted gene can be overexpressed, underexpressed, or disrupted to the extent that its functionis ablated (a gene knock-out). Second, one can seek genes that are identified as important because they are differentially expressed. Third, one can seek variations in the sequence of genes that are associated with alcohol sensitivity. The first approach can only be attempted using genetic animal models. Each approach will be reviewed, with an emphasis on the second and third. The examples of statistical measures will be present, the differences between family designed studies and association studies in compare to unrelated healthy volunteers will be discussed.

Abstract

The familial occurence of alcoholism has been known for many years. Approximatly 50–60% of individual differences in risk for alcoholism is genetic, and this proportion is approximately equal in man and woman. The goal of this article is to review the current status in the search for “candidate gens” for alcohol dependence. There are three basic approaches to identifying important genes. First, one can target genes based on their presumed importance in influencing alcohol sensitivity. The targeted gene can be overexpressed, underexpressed, or disrupted to the extent that its functionis ablated (a gene knock-out). Second, one can seek genes that are identified as important because they are differentially expressed. Third, one can seek variations in the sequence of genes that are associated with alcohol sensitivity. The first approach can only be attempted using genetic animal models. Each approach will be reviewed, with an emphasis on the second and third. The examples of statistical measures will be present, the differences between family designed studies and association studies in compare to unrelated healthy volunteers will be discussed.
Get Citation

Keywords

molecular-genetic investigations; alcohol dependence; alcohol withdrawal; assotiation and linkage studies; „knock-out” technology; QTL; TDT

About this article
Title

Addiction pathogenesis in genetic research

Journal

Psychiatria (Psychiatry)

Issue

Vol 2, No 1 (2005)

Article type

Review paper

Pages

9-18

Published online

2004-12-08

Bibliographic record

Psychiatria 2005;2(1):9-18.

Keywords

molecular-genetic investigations
alcohol dependence
alcohol withdrawal
assotiation and linkage studies
„knock-out” technology
QTL
TDT

Authors

Agnieszka Samochowiec
Agnieszka Mordasewicz
Georg Arentowicz
Jerzy Samochowiec

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

Wydawcą serwisu jest Via Medica sp. z o.o. sp. komandytowa, ul. Świętokrzyska 73, 80–180 Gdańsk

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail:  viamedica@viamedica.pl