open access

Vol 2, No 3 (2005)
Review paper
Published online: 2005-09-27
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Are schizophrenia and bipolar disorders genetically related?

Joanna Hauser, Anna Leszczyńska-Rodziewicz, Maria Skibińska
Psychiatria 2005;2(3):145-153.

open access

Vol 2, No 3 (2005)
Prace poglądowe - nadesłane
Published online: 2005-09-27

Abstract

For more than hundred years research in psychiatry has proceed under the assumption that bipolar disorder and schizophrenia are distinct entities, with separate underlying disease process and treatment. It is predicted that in coming years molecular genetic studies will overturn this traditional dichotomous view. The article reviews evidence that bipolar disorder (BP) and schizophrenia (SCH) might share familial risk characteristics. Family studies of BP and SCH suggest partial overlap in familial susceptibility. Molecular linkage studies indicates that some susceptibility loci may be common for both nosological classes. Current evidence supports DAOA, DISC1 and COMT as schizophrenia and bipolar disorder susceptibility loci. Some research suggests, that there might be a genetic connection between schizophrenia and bipolar disorder. Future identification of psychosis susceptibility genes will have a major impact on our understanding of disease pathophysiology.

Abstract

For more than hundred years research in psychiatry has proceed under the assumption that bipolar disorder and schizophrenia are distinct entities, with separate underlying disease process and treatment. It is predicted that in coming years molecular genetic studies will overturn this traditional dichotomous view. The article reviews evidence that bipolar disorder (BP) and schizophrenia (SCH) might share familial risk characteristics. Family studies of BP and SCH suggest partial overlap in familial susceptibility. Molecular linkage studies indicates that some susceptibility loci may be common for both nosological classes. Current evidence supports DAOA, DISC1 and COMT as schizophrenia and bipolar disorder susceptibility loci. Some research suggests, that there might be a genetic connection between schizophrenia and bipolar disorder. Future identification of psychosis susceptibility genes will have a major impact on our understanding of disease pathophysiology.
Get Citation

Keywords

genetics; schizophrenia; bipolar disorder

About this article
Title

Are schizophrenia and bipolar disorders genetically related?

Journal

Psychiatria (Psychiatry)

Issue

Vol 2, No 3 (2005)

Article type

Review paper

Pages

145-153

Published online

2005-09-27

Bibliographic record

Psychiatria 2005;2(3):145-153.

Keywords

genetics
schizophrenia
bipolar disorder

Authors

Joanna Hauser
Anna Leszczyńska-Rodziewicz
Maria Skibińska

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