open access

Vol 2, No 4 (2005)
Research paper
Published online: 2006-02-21
Get Citation

Comparison of choose immune system parameters in patients suffering from depression and healthy donors

Krzysztof Pietruczuk, Katarzyna Jakuszkowiak, Jerzy Landowski, Jacek M. Witkowski
Psychiatria 2005;2(4):210-216.

open access

Vol 2, No 4 (2005)
Prace oryginalne - nadesłane
Published online: 2006-02-21

Abstract


Background. Depressive disorders are a serious and frequent challenge for contemporary medicine. The understanding of basic pathophysiological and etiological principles of depression is still poor. According to the immunological hypothesis of depression, dysregulation of nervous system may induce dysregulation of the immune system or vice versa. The aim of current study was to assess the differences in the mitochondrial membrane potential and in the level of activation antigens CD25 and CD69 between peripheral blood T lymphocytes of healthy people and people who suffer from depression.
Materials and methods. JC-1 - a fluorescent mitochondrial membrane potential probe - and flow cytometry were used for comparison of the levels of mitochondrial potential in the T cells of patients with diagnosed depressive episode (ICD-10 diagnostic criteria) and from healthy people. Flow cytometry was also used for assessment of phenotype differences.
Results. Mitochondrial potential in the lymphocytes of people who suffer from depression was decreased in comparison with healthy control, pointing at the possibility of impaired energy production in these cells. At the same time we observed a significant increase of percentages of both CD4+CD25+ and CD8+CD25+ as well as CD8+CD69+ lymphocytes in depressive patients, suggesting increased levels of lymphocyte activation associated with the disease.
Conclusions. There is an association between depression and the immune system state.

Abstract


Background. Depressive disorders are a serious and frequent challenge for contemporary medicine. The understanding of basic pathophysiological and etiological principles of depression is still poor. According to the immunological hypothesis of depression, dysregulation of nervous system may induce dysregulation of the immune system or vice versa. The aim of current study was to assess the differences in the mitochondrial membrane potential and in the level of activation antigens CD25 and CD69 between peripheral blood T lymphocytes of healthy people and people who suffer from depression.
Materials and methods. JC-1 - a fluorescent mitochondrial membrane potential probe - and flow cytometry were used for comparison of the levels of mitochondrial potential in the T cells of patients with diagnosed depressive episode (ICD-10 diagnostic criteria) and from healthy people. Flow cytometry was also used for assessment of phenotype differences.
Results. Mitochondrial potential in the lymphocytes of people who suffer from depression was decreased in comparison with healthy control, pointing at the possibility of impaired energy production in these cells. At the same time we observed a significant increase of percentages of both CD4+CD25+ and CD8+CD25+ as well as CD8+CD69+ lymphocytes in depressive patients, suggesting increased levels of lymphocyte activation associated with the disease.
Conclusions. There is an association between depression and the immune system state.
Get Citation

Keywords

depression; T cells; mitochondrial potential

About this article
Title

Comparison of choose immune system parameters in patients suffering from depression and healthy donors

Journal

Psychiatria (Psychiatry)

Issue

Vol 2, No 4 (2005)

Article type

Research paper

Pages

210-216

Published online

2006-02-21

Bibliographic record

Psychiatria 2005;2(4):210-216.

Keywords

depression
T cells
mitochondrial potential

Authors

Krzysztof Pietruczuk
Katarzyna Jakuszkowiak
Jerzy Landowski
Jacek M. Witkowski

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

Wydawcą serwisu jest Via Medica sp. z o.o. sp. komandytowa, ul. Świętokrzyska 73, 80–180 Gdańsk

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail:  viamedica@viamedica.pl