open access

Vol 3, No 4 (2006)
Research paper
Published online: 2006-12-08
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The effect of escitalopram and nortryptyline on pain symptoms in major depression

Jan Jaracz, Karolina Gattner, Joanna Hauser
Psychiatria 2006;3(4):143-147.

open access

Vol 3, No 4 (2006)
Prace oryginalne - nadesłane
Published online: 2006-12-08

Abstract


Introduction. Pain symptoms are commonly reported by patients with major depression. The aim of this study was to compare the effect of escitalopram (SSRI, selective serotonin reuptake inhibitor) and nortryptyline (NARI, norepinephrine reuptake inhibitor) on pain symptoms in depressed patients.
Material and methods. Patients (mean age: 39.4) meeting the diagnostic criteria of depressive episode were randomly assigned to 8 week treatment with escitalopram 10-20 mg/day or nortryptyline 150 mg/day. Pain symptoms were identified at baseline and every 2 weeks of treatment. Intensity of pain was assessed with Visual Analogue Scale (VAS). The 17-items Hamilton Depression Rating Scale (HDRS) was used to assess the response to treatment.
Results and conclusions. At baseline, 37 patients (78%) reported one or more (mean 2.65) pain symptoms (headaches, pain in neck and abdomen). Escitalopram and nortryptyline caused similar improvement in pain symptoms and depression. The presence of pain symptoms at baseline did not predict the therapeutic clinical response after 8 weeks of treatment.

Abstract


Introduction. Pain symptoms are commonly reported by patients with major depression. The aim of this study was to compare the effect of escitalopram (SSRI, selective serotonin reuptake inhibitor) and nortryptyline (NARI, norepinephrine reuptake inhibitor) on pain symptoms in depressed patients.
Material and methods. Patients (mean age: 39.4) meeting the diagnostic criteria of depressive episode were randomly assigned to 8 week treatment with escitalopram 10-20 mg/day or nortryptyline 150 mg/day. Pain symptoms were identified at baseline and every 2 weeks of treatment. Intensity of pain was assessed with Visual Analogue Scale (VAS). The 17-items Hamilton Depression Rating Scale (HDRS) was used to assess the response to treatment.
Results and conclusions. At baseline, 37 patients (78%) reported one or more (mean 2.65) pain symptoms (headaches, pain in neck and abdomen). Escitalopram and nortryptyline caused similar improvement in pain symptoms and depression. The presence of pain symptoms at baseline did not predict the therapeutic clinical response after 8 weeks of treatment.
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Keywords

depression; pain; escitalopram; nortryptyline

About this article
Title

The effect of escitalopram and nortryptyline on pain symptoms in major depression

Journal

Psychiatria (Psychiatry)

Issue

Vol 3, No 4 (2006)

Article type

Research paper

Pages

143-147

Published online

2006-12-08

Bibliographic record

Psychiatria 2006;3(4):143-147.

Keywords

depression
pain
escitalopram
nortryptyline

Authors

Jan Jaracz
Karolina Gattner
Joanna Hauser

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