open access

Vol 4, No 1 (2007)
Review paper
Published online: 2007-02-20
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The influence of the first generation mood-stabilizing drugs (lithium,valproate, carbamazepine) on body weight and carbohydrate metabolism in patients with bipolar affective disorder

Katarzyna Olszewska, Janusz Rybakowski
Psychiatria 2007;4(1):8-16.

open access

Vol 4, No 1 (2007)
Prace poglądowe - nadesłane
Published online: 2007-02-20

Abstract

Lithium, valproate, carbamazepine belong to the first generation of mood-stabilizing drugs. They are mainly indicated as the pharmacological prophylaxis of relapse in bipolar affective disorder. Accordingly, these drugs must be given in a majority of patients for a long time. A common reason for discontinuation of treatment are adverse effects, including undesirable metabolic side effects. Their manifestation are: weight gain and abnormalities in carbohydrate metabolism. Particularly weight gain, occurring from the early stages of lithium or valproate therapy, often leads to discontinuation of treatment. Weight gain and hyperglicaemia may increase during therapy. This may also result in the increase of cardiovascular risk in these patients.

Abstract

Lithium, valproate, carbamazepine belong to the first generation of mood-stabilizing drugs. They are mainly indicated as the pharmacological prophylaxis of relapse in bipolar affective disorder. Accordingly, these drugs must be given in a majority of patients for a long time. A common reason for discontinuation of treatment are adverse effects, including undesirable metabolic side effects. Their manifestation are: weight gain and abnormalities in carbohydrate metabolism. Particularly weight gain, occurring from the early stages of lithium or valproate therapy, often leads to discontinuation of treatment. Weight gain and hyperglicaemia may increase during therapy. This may also result in the increase of cardiovascular risk in these patients.
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Keywords

mood-stabilizing drugs; bipolar affective disorder; weight gain; hyperglicaemia

About this article
Title

The influence of the first generation mood-stabilizing drugs (lithium,valproate, carbamazepine) on body weight and carbohydrate metabolism in patients with bipolar affective disorder

Journal

Psychiatria (Psychiatry)

Issue

Vol 4, No 1 (2007)

Article type

Review paper

Pages

8-16

Published online

2007-02-20

Bibliographic record

Psychiatria 2007;4(1):8-16.

Keywords

mood-stabilizing drugs
bipolar affective disorder
weight gain
hyperglicaemia

Authors

Katarzyna Olszewska
Janusz Rybakowski

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