Pseudo-resistance to drug therapy

Abstract

As many studies have proved, about 20-30% schizophrenic patients do not response on proper pharmacological treatment. This problem, called pharmacoresistance, is not always the result of a lack of drug effectiveness. It is often caused by irregular treatment, dose decreasing or drug withdrawal by the patient.
This paper describes a lack of patient compliance and its causes as well as attempts to break down the barriers. Some European researches findings on compliance in schizophrenia treatment (eg ADHES) are presented. The problem is equally common among patients in all European countries.
Clinical observations show benefits of long-acting drugs in out-patient setting as a high efficient treatment.