open access

Vol 4, No 4 (2007)
Research paper
Published online: 2007-10-31
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Association between polymorphisms of 1287 A/G noradrenaline transporter gene and drug response for escitalopram and nortriptyline in depressed patients

Aleksandra Rajewska-Rager, Paweł Kapelski, Monika Dmitrzak-Węglarz, Maria Skibińska, Aleksandra Szczepankiewicz, Joanna Hauser
Psychiatria 2007;4(4):139-143.

open access

Vol 4, No 4 (2007)
Prace oryginalne - nadesłane
Published online: 2007-10-31

Abstract

Introduction. The aim of this study was to analyze the possible association of the candidate gene of noradrenergic system - noradrenaline transporter with efficacy of antidepressant treatment.
Material and methods. In the study we analyzed 90 patients with major depression (21 males and 69 females) with a mean age of 38 years, suffering from depressive disorder of at least moderate severity, meeting the research criteria of ICD-10 and DSM-IV for major depression. Patients were randomized into two groups: 1) patients received the serotoninergic drug - escitalopram (n = 51) with specified dose range 10-20 mg/day. 2) Patients treated by noradrenergic drug - nortriptyline (n = 49) with dose range 75-150 mg/day. The response to the drug was defined by a reduction ≥ 50% of total score of Hamilton scale in the 8 week of treatment in comparison to the week 0. Genotypes for 1287A/G NET gene polymorphisms were established by PCR-RFLP method. Statistical analysis was performed with Statistica version 7.1.
Results. We have not found an association of 1287A/G polymorphism of NET gene with treatment response neither to escitalopram (p = 0.767 for genotypes, p = 0.651 for alleles) nor to nortriptyline (p = 0.471 for genotypes, p = 0.484 for alleles) when comparing the group of patients with response to the group of patients without response to the drugs.
Conclusions. The polymorphisms of NET gene analyzed in this study are not likely to be associated with treatment response to antidepressants, neither escitalopram nor nortriptyline in our group of patients with depression.

Abstract

Introduction. The aim of this study was to analyze the possible association of the candidate gene of noradrenergic system - noradrenaline transporter with efficacy of antidepressant treatment.
Material and methods. In the study we analyzed 90 patients with major depression (21 males and 69 females) with a mean age of 38 years, suffering from depressive disorder of at least moderate severity, meeting the research criteria of ICD-10 and DSM-IV for major depression. Patients were randomized into two groups: 1) patients received the serotoninergic drug - escitalopram (n = 51) with specified dose range 10-20 mg/day. 2) Patients treated by noradrenergic drug - nortriptyline (n = 49) with dose range 75-150 mg/day. The response to the drug was defined by a reduction ≥ 50% of total score of Hamilton scale in the 8 week of treatment in comparison to the week 0. Genotypes for 1287A/G NET gene polymorphisms were established by PCR-RFLP method. Statistical analysis was performed with Statistica version 7.1.
Results. We have not found an association of 1287A/G polymorphism of NET gene with treatment response neither to escitalopram (p = 0.767 for genotypes, p = 0.651 for alleles) nor to nortriptyline (p = 0.471 for genotypes, p = 0.484 for alleles) when comparing the group of patients with response to the group of patients without response to the drugs.
Conclusions. The polymorphisms of NET gene analyzed in this study are not likely to be associated with treatment response to antidepressants, neither escitalopram nor nortriptyline in our group of patients with depression.
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Keywords

depression; noradrenaline transporter; escitalopram; nortryptyline

About this article
Title

Association between polymorphisms of 1287 A/G noradrenaline transporter gene and drug response for escitalopram and nortriptyline in depressed patients

Journal

Psychiatria (Psychiatry)

Issue

Vol 4, No 4 (2007)

Article type

Research paper

Pages

139-143

Published online

2007-10-31

Bibliographic record

Psychiatria 2007;4(4):139-143.

Keywords

depression
noradrenaline transporter
escitalopram
nortryptyline

Authors

Aleksandra Rajewska-Rager
Paweł Kapelski
Monika Dmitrzak-Węglarz
Maria Skibińska
Aleksandra Szczepankiewicz
Joanna Hauser

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