Tom 4, Nr 4 (2007)
Artykuł przeglądowy
Opublikowany online: 2007-10-31
Interakcja czynników genetycznych i środowiskowych w schizofrenii
Psychiatria 2007;4(4):153-159.
Streszczenie
The purpose of this article is to present research that test hypotheses of gene-environment interaction (GxE) in
schizophrenia. Family, twins studies indicate that genetic factor cannot explain the entirety of liability to schizophrenia,
and that the environment plays a non-trivial role. Risk to overt schizophrenia is then an integrated function
of numerous predisposing genes, environmental factors and their interactions. Gene-environment interactions
were thought to be rare in psychiatry, but now clinical findings of measured GxE are emerging. The authors
synthesize findings of studies implicating genes, cannabis use, brain injury, migration, obstetric complications as
risk factor for the development of schizophrenia. Second, we summarize the emerging evidence about GxE in
schizophrenia, we also describe strategies that may be used to further studies of GxE
Słowa kluczowe: schizofreniainterakcja czynników genetycznych i środowiskowych