open access

Vol 5, No 2 (2008)
Research paper
Published online: 2008-05-30
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The influence of the single evening dose of estazolam on serum cortisol morning level in population without hypothalamic-pituitary-adrenal axis pathology

Michał Siek, Sonia Kaniuka, Łukasz Obołończyk, Piotr Wiśniewski, Krzysztof Sworczak
Psychiatria 2008;5(2):37-42.

open access

Vol 5, No 2 (2008)
Prace oryginalne - nadesłane
Published online: 2008-05-30

Abstract


Introduction. The hypothalamic neurohormones: corticoliberin and vasopressin and the negative feedback mechanism are responsible for neuronal control of the hypothalamic-pituitary-adrenal axis (HPA). In regulation of that axis participate also other neuropeptides and neurotransmitters among which gamma-aminobutyric acid (GABA) plays significant role. An increasing interest of this neuromediator is mainly caused by widespread usage of benzodiazepines' derivatives in therapeutics. The aim of the study was to estimate the influence of estazolam on serum cortisol concentration in population of young, healthy people.
Material and methods. The study group consisted of 30 people above 18 years old, who have never used benzodiazepines before. Those who might have had incorrect cortisol secretion were excluded. Every person had their blood taken twice (at 8 a.m. before taking benzodiazepine and at 8 a.m. the following day after taking at 10 p.m. of the previous day 2 mg of estazolam). The cortisol level in serum was determined by immunoenzymatic method using commercial kit. The data were statistically analyzed using Wilcoxon and ANOVA tests.
Results. The mean level of cortisol in study group before taking 2 mg of estazolam was 549.64 nmol/l (SD 221.51), while after taking the drug was 472.26 nmol/l (SD 223.63). The difference was statistically significant with p = 0.004. There was no statistically significant difference in decrease of serum cortisol level after estazolam administration between women and men.
Conclusions. Using 2 mg of estazolam before sleep have caused statistically significant decrease of serum cortisol level in population of young people without pathology of the HPA axis.

Abstract


Introduction. The hypothalamic neurohormones: corticoliberin and vasopressin and the negative feedback mechanism are responsible for neuronal control of the hypothalamic-pituitary-adrenal axis (HPA). In regulation of that axis participate also other neuropeptides and neurotransmitters among which gamma-aminobutyric acid (GABA) plays significant role. An increasing interest of this neuromediator is mainly caused by widespread usage of benzodiazepines' derivatives in therapeutics. The aim of the study was to estimate the influence of estazolam on serum cortisol concentration in population of young, healthy people.
Material and methods. The study group consisted of 30 people above 18 years old, who have never used benzodiazepines before. Those who might have had incorrect cortisol secretion were excluded. Every person had their blood taken twice (at 8 a.m. before taking benzodiazepine and at 8 a.m. the following day after taking at 10 p.m. of the previous day 2 mg of estazolam). The cortisol level in serum was determined by immunoenzymatic method using commercial kit. The data were statistically analyzed using Wilcoxon and ANOVA tests.
Results. The mean level of cortisol in study group before taking 2 mg of estazolam was 549.64 nmol/l (SD 221.51), while after taking the drug was 472.26 nmol/l (SD 223.63). The difference was statistically significant with p = 0.004. There was no statistically significant difference in decrease of serum cortisol level after estazolam administration between women and men.
Conclusions. Using 2 mg of estazolam before sleep have caused statistically significant decrease of serum cortisol level in population of young people without pathology of the HPA axis.
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Keywords

estazolam; cortisol; hypothalamic-pituitary-adrenal axis

About this article
Title

The influence of the single evening dose of estazolam on serum cortisol morning level in population without hypothalamic-pituitary-adrenal axis pathology

Journal

Psychiatria (Psychiatry)

Issue

Vol 5, No 2 (2008)

Article type

Research paper

Pages

37-42

Published online

2008-05-30

Bibliographic record

Psychiatria 2008;5(2):37-42.

Keywords

estazolam
cortisol
hypothalamic-pituitary-adrenal axis

Authors

Michał Siek
Sonia Kaniuka
Łukasz Obołończyk
Piotr Wiśniewski
Krzysztof Sworczak

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