open access

Vol 5, No 2 (2008)
Review paper
Published online: 2008-05-30
Get Citation

Cognitive dysfunctions and depression in Alzheimer´s disease, the neurobiological aspects

Jerzy Daniluk, Alina Borkowska
Psychiatria 2008;5(2):43-50.

open access

Vol 5, No 2 (2008)
Prace poglądowe - nadesłane
Published online: 2008-05-30

Abstract

Cognitive dysfunctions are core element of clinical picture of the Alzheimer's Disease (AD) and may occurred few years before full AD as a mild cognitive impairment (MCI). The more frequent psychiatric disturbance coexisted with AD is depression, which may increase cognitive dysfunctions especially connected with abnormal activation of the frontal cortex. The current data indicated the importance of cognitive and affective endophenotypes of AD, which may be known as a markers of progression MCI to AD. In etiopathogenesis of cognitive dysfunctions and affective symptoms in AD the serotonin transporter gene and BDNF, especially of Val66Met polymorphism may play important role.

Abstract

Cognitive dysfunctions are core element of clinical picture of the Alzheimer's Disease (AD) and may occurred few years before full AD as a mild cognitive impairment (MCI). The more frequent psychiatric disturbance coexisted with AD is depression, which may increase cognitive dysfunctions especially connected with abnormal activation of the frontal cortex. The current data indicated the importance of cognitive and affective endophenotypes of AD, which may be known as a markers of progression MCI to AD. In etiopathogenesis of cognitive dysfunctions and affective symptoms in AD the serotonin transporter gene and BDNF, especially of Val66Met polymorphism may play important role.
Get Citation

Keywords

Alzheimer´s disease; cognitive functions; neurobiology

About this article
Title

Cognitive dysfunctions and depression in Alzheimer´s disease, the neurobiological aspects

Journal

Psychiatria (Psychiatry)

Issue

Vol 5, No 2 (2008)

Article type

Review paper

Pages

43-50

Published online

2008-05-30

Bibliographic record

Psychiatria 2008;5(2):43-50.

Keywords

Alzheimer´s disease
cognitive functions
neurobiology

Authors

Jerzy Daniluk
Alina Borkowska

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

Wydawcą serwisu jest Via Medica sp. z o.o. sp. komandytowa, ul. Świętokrzyska 73, 80–180 Gdańsk

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail:  viamedica@viamedica.pl