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Vol 7, No 2 (2010)
Review paper
Published online: 2010-06-10

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Genes associated with stress response in the pathogenesis of unipolar and bipolar affective disorders

Aleksandra Szczepankiewicz, Anna Leszczyńska-Rodziewicz
Psychiatria 2010;7(2):61-67.

Abstract

Dysregulation of hypothalamic-pituitary-adrenocortical axis (HPA) is very important for development of affective disorders such as bipolar disorder and depression. The key role play so called stressor from the environment that leads to disturbed regulation of HPA axis and subsequent development of both mentioned disorders.
Due to high heritability of bipolar affective disorder and depression genetic background of dysregulated HPA axis was extensively analyzed. The most important seem three pathways associated with adrenocorticotropin, vasopressin and glucocorticoids. Several candidate genes have been identified including genes encoding hormones, their receptors and secondary messenger systems.
In the present work we discussed the role of genes associated with dysregulation of HPA axis in the pathogenesis of bipolar affective disorder and depression including differential clinical subtypes.
Psychiatry 2010; 7, 2: 61-67

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