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Vol 7, No 4 (2010)
Research paper
Published online: 2010-09-13
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The impact of the early subjective response to antipsychotic treatment on the course of their illness in a group of schizophrenic patients under long-term observation

Sławomir Murawiec
Psychiatria 2010;7(4):143-151.

open access

Vol 7, No 4 (2010)
Prace oryginalne - nadesłane
Published online: 2010-09-13

Abstract


Introduction. Research into the significance of early subjective response to antipsychotic medication has so far only involved observation periods of up to 1 year.
Material and methods. The Drug Attitude Inventory (DAI-10) questionnaires, completed by schizophrenic patients in 1997-1998, have been used in this research. In 2009, data on 36 patients were found whose completed DAI questionnaires were on record in the hospital register. The data included the number of hospitalizations, which enabled to calculate the total number of hospitalized days for each patient, following which a statistical analysis was conducted, which looked into possible correlations between the DAI scale results and the number of hospitalizations in 1997/1998–2009 and the number of days spent in the hospital during that period of time.
Results. Data has been obtained for 36 patients, comprising 18 women and 18 men. The total number of hospitalizations in the period of 11-12 years has shown no correlations with the results of DAI-10 scale (p = 0.23). However, the number of days spent in hospital in the period of catamnesis has shown a reverse correlation between the results of the DAI-10 scale in 1997–1998 and the number of hospitalized days (p = 0.037). The higher was the result of DAI-10 scale in 1997-1998, the fewer days of hospitalization were found in the researched period. The research group was divided according on the values of the DAI-10 scale into two subgroups. In the group of patients with the values 10-17, the median number of hospitalizations was 10,0 (± 5.0-14), and the number of hospitalized days was 554.0 (± 251-1082). In the group of patients with early positive response (the values of DAI 18-20), the median number of hospitalizations was 5.0 (± 2.5-8), and the number of hospitalized days was 211.0 (± 62-390.5). These variations were statistically significant.
Conclusions. Early subjective response to antipsychotic drugs shows a relation to the number of hospitalized days in the period of observation over 10 years.
Psychiatry 2010; 7, 4: 143-150

Abstract


Introduction. Research into the significance of early subjective response to antipsychotic medication has so far only involved observation periods of up to 1 year.
Material and methods. The Drug Attitude Inventory (DAI-10) questionnaires, completed by schizophrenic patients in 1997-1998, have been used in this research. In 2009, data on 36 patients were found whose completed DAI questionnaires were on record in the hospital register. The data included the number of hospitalizations, which enabled to calculate the total number of hospitalized days for each patient, following which a statistical analysis was conducted, which looked into possible correlations between the DAI scale results and the number of hospitalizations in 1997/1998–2009 and the number of days spent in the hospital during that period of time.
Results. Data has been obtained for 36 patients, comprising 18 women and 18 men. The total number of hospitalizations in the period of 11-12 years has shown no correlations with the results of DAI-10 scale (p = 0.23). However, the number of days spent in hospital in the period of catamnesis has shown a reverse correlation between the results of the DAI-10 scale in 1997–1998 and the number of hospitalized days (p = 0.037). The higher was the result of DAI-10 scale in 1997-1998, the fewer days of hospitalization were found in the researched period. The research group was divided according on the values of the DAI-10 scale into two subgroups. In the group of patients with the values 10-17, the median number of hospitalizations was 10,0 (± 5.0-14), and the number of hospitalized days was 554.0 (± 251-1082). In the group of patients with early positive response (the values of DAI 18-20), the median number of hospitalizations was 5.0 (± 2.5-8), and the number of hospitalized days was 211.0 (± 62-390.5). These variations were statistically significant.
Conclusions. Early subjective response to antipsychotic drugs shows a relation to the number of hospitalized days in the period of observation over 10 years.
Psychiatry 2010; 7, 4: 143-150
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Keywords

schizophrenia; pharmacotherapy; subjective aspects; prognosis

About this article
Title

The impact of the early subjective response to antipsychotic treatment on the course of their illness in a group of schizophrenic patients under long-term observation

Journal

Psychiatria (Psychiatry)

Issue

Vol 7, No 4 (2010)

Article type

Research paper

Pages

143-151

Published online

2010-09-13

Bibliographic record

Psychiatria 2010;7(4):143-151.

Keywords

schizophrenia
pharmacotherapy
subjective aspects
prognosis

Authors

Sławomir Murawiec

References (16)
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