Vol 7, No 5 (2010)
Review paper
Published online: 2010-11-15
Comorbidity of depressive and anxiety disorders
Psychiatria 2010;7(5):189-197.
Abstract
The authors present the problem of comorbidity of anxiety disorders and depressive disorders. Although anxiety
is one of the most common concomitant symptoms of depression, International Statistical Classification of Diseases
and Related Health Problems (Tenth Revision) and Diagnostic and Statistical Manual of Mental Disorders
(Fourth Edition, Text Revision) classifications do not mention it among diagnostic criteria of depressive disorders.
Comorbidity of those medical states is associated with more severe clinical course and greater drop-out risk.
Generalized anxiety disorder is the most common comorbid anxiety disorder accompanying major depressive
disorder. The latter is - on the other hand - the most prevalent complication of obsessive-compulsive disorder.
Pathogenesis of the comorbidity of anxiety disorders and depressive disorders is explained by neuroendocrine,
monoamine and psychological models. Data on the comorbid anxiety and depressive disorders is relatively scarce.
Therapeutic strategies used in these conditions can be divided into sequential and concurrent ones.
Psychiatry 2010; 7, 5: 189-197
Psychiatry 2010; 7, 5: 189-197
Keywords: major depressive disorderanxiety disordersanxiety-depressive disorderscomorbidity
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