open access

Vol 8, No 2 (2011)
Review paper
Published online: 2011-06-17
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Metabolic syndrome and depressive disorders — literature review

Adam Wysokiński, Iwona Kłoszewska
Psychiatria 2011;8(2):46-52.

open access

Vol 8, No 2 (2011)
Prace poglądowe - nadesłane
Published online: 2011-06-17

Abstract

The authors have reviewed the literature on the occurrence of metabolic syndrome in patients with depressive disorders. The incidence of metabolic syndrome is presented, causal relationship between depression and metabolic disorders, mechanisms underlying their pathogenesis and the influence of antidepressive therapy are discussed. Various groups of antidepressants were compared for their effect on metabolic disorders. Our data show that metabolic syndrome is very common in the discussed population (30–40%), its incidence is the highest among patients treated with tricyclic antidepressants, mirtazapine and slightly less frequent in patients taking SSRIs. Weight gain and metabolic disorders are the least common in patients treated with reboxetine, bupropion and SNRIs (venlafaxine, duloxetine). Since clinical consequences of metabolic syndrome are severe, metabolic parameters of patients with depressive disorders should be regularly monitored.
Psychiatry 2011; 8, 2: 46–52

Abstract

The authors have reviewed the literature on the occurrence of metabolic syndrome in patients with depressive disorders. The incidence of metabolic syndrome is presented, causal relationship between depression and metabolic disorders, mechanisms underlying their pathogenesis and the influence of antidepressive therapy are discussed. Various groups of antidepressants were compared for their effect on metabolic disorders. Our data show that metabolic syndrome is very common in the discussed population (30–40%), its incidence is the highest among patients treated with tricyclic antidepressants, mirtazapine and slightly less frequent in patients taking SSRIs. Weight gain and metabolic disorders are the least common in patients treated with reboxetine, bupropion and SNRIs (venlafaxine, duloxetine). Since clinical consequences of metabolic syndrome are severe, metabolic parameters of patients with depressive disorders should be regularly monitored.
Psychiatry 2011; 8, 2: 46–52
Get Citation

Keywords

metabolic syndrome; depressive disorders; antidepressants

About this article
Title

Metabolic syndrome and depressive disorders — literature review

Journal

Psychiatria (Psychiatry)

Issue

Vol 8, No 2 (2011)

Article type

Review paper

Pages

46-52

Published online

2011-06-17

Bibliographic record

Psychiatria 2011;8(2):46-52.

Keywords

metabolic syndrome
depressive disorders
antidepressants

Authors

Adam Wysokiński
Iwona Kłoszewska

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