Tom 14, Nr 3 (2018)
Opis przypadku
Opublikowany online: 2018-11-21
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Przewlekłe limfocytarne zapalenie mostu i móżdżku (CLIPPERS) — opis przypadku
Pol. Przegl. Neurol 2018;14(3):178-182.
Streszczenie
Zespół przewlekłego limfocytarnego zapalenia mostu i móżdżku (CLIPPERS, chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids) jest bardzo rzadkim schorzeniem zapalnym ośrodkowego układu nerwowego o nieustalonej etiologii. Schorzenie to charakteryzuje się podostrym przebiegiem, różnorodnym obrazem klinicznym w wyniku zajęcia pnia mózgu, nerwów czaszkowych i/lub móżdżku oraz bardzo dobrą odpowiedzią na leczenie glikokortykosteroidami. Autorzy przedstawili przypadek kobiety w wieku 34 lat, u której na podstawie obrazu klinicznego oraz badań pomocniczych rozpoznano zespół CLIPPERS.
Słowa kluczowe: CLIPPERSzapalenie pnia mózguzapalenie naczyń mózgowychvasculitis
Referencje
- Tobin WO, Guo Y, Krecke KN, et al. Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS). Brain. 2010; 133(9): 2626–2634.
- Bladowska J, Waliszewska-Prosół M, Rojek A, et al. Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids Syndrome: Diagnostic Challenge of the Brainstem Inflammation. Eur Neurol. 2017; 77(1–2): 103–104.
- Dudesek A, Rimmele F, Tesar S, et al. CLIPPERS: chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids. Review of an increasingly recognized entity within the spectrum of inflammatory central nervous system disorders. Clin Exp Immunol. 2014; 175(3): 385–396.
- Ito M, Kuwabara S, Odaka M, et al. Bickerstaff's brainstem encephalitis and Fisher syndrome form a continuous spectrum. J. Neurol. 2008; 255(5): 674–682.
- Taieb G, Duflos C, Renard D, et al. Long-term outcomes of CLIPPERS (chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids) in a consecutive series of 12 patients. Arch Neurol. 2012; 69(7): 847–855.
- Kerrn-Jespersen BM, Lindelof M, Illes Z, et al. CLIPPERS among patients diagnosed with non-specific CNS neuroinflammatory diseases. J Neurol Sci. 2014; 343(1–2): 224–227.
- Wang X, Huang D, Huang X, et al. Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS): A lymphocytic reactive response of the central nervous system? A case report. J Neuroimmunol. 2017; 305: 68–71.
- Symmonds M, Waters PJ, Küker W, et al. Anti-MOG antibodies with longitudinally extensive transverse myelitis preceded by CLIPPERS. Neurology. 2015; 84(11): 1177–1179.
- Simon NG, Parratt JD, Barnett MH, et al. Expanding the clinical, radiological and neuropathological phenotype of chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS). J Neurol Neurosurg Psychiatry. 2012; 83(1): 15–22.
- List J, Lesemann A, Wiener E, et al. A new case of chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids. Brain. 2011; 134(8): e185.
- Tobin W, Guo Y, Krecke K, et al. Diagnostic criteria for chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS). Brain. 2017; 140(9): 2415–2425.
- Buttmann M, Metz I, Brecht I, et al. Atypical chronic lymphocytic inflammation with pontocerebellar perivascular enhancement responsive to steroids (CLIPPERS), primary angiitis of the CNS mimicking CLIPPERS or overlap syndrome? A case report. J Neurol Sci. 2013; 324(1–2): 183–186.
- Nakamura R, Ueno Y, Ando J, et al. Clinical and radiological CLIPPERS features after complete remission of peripheral T-cell lymphoma, not otherwise specified. J Neurol Sci. 2016; 364: 6–8.
- Jones JL, Dean AF, Antoun N, et al. 'Radiologically compatible CLIPPERS' may conceal a number of pathologies. Brain. 2011; 134(8): e187.
- Limousin N, Praline J, Motica O, et al. Brain biopsy is required in steroid-resistant patients with chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS). J Neurooncol. 2012; 107(1): 223–224.
- De Graaff HJ, Wattjes MP, Rozemuller-Kwakkel AJ, et al. Fatal B-cell lymphoma following chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids. JAMA Neurol. 2013; 70(7): 915–918.
- Gabilondo I, Saiz A, Graus F, et al. Response to immunotherapy in CLIPPERS syndrome. J Neurol. 2011; 258(11): 2090–2092.
