Wpływ inhibitorów konwertazy angiotensyny na zdolności poznawcze
Streszczenie
Inhibitory konwertazy angiotensyny (ACEI, angiotensin-converting enzyme inhibitors) są ważną grupą leków w farmakoterapii hipotensyjnej. Kluczowymi lekami wchodzącymi w skład tej grupy
są miedzy innymi perindopril, kaptopril, lisinopril. Leki te mają nie tylko działanie hipotensyjne. Wykazano poprawę zdolności poznawczych u pacjentów stosujących ACEI z otępieniem nie tylko
w przypadku otępienia pochodzenia naczyniowego. Poza hamowaniem enzymu odpowiedzialnego za wytwarzanie angiotensyny II ACEI hamują powstawanie stresu oksydacyjnego i stanu zapalnego. W niniejszej pracy dokonano analizy potencjalnych możliwości zastosowania ACEI w farmakoterapii zaburzeń otępiennych.
Słowa kluczowe: angiotensynakonwertazaneurodegeneracjaotępienieperindopril
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