Comparison of clinical characteristics, in-hospital course, and 12-month prognosis in women and men with chronic coronary syndromes

Abstract

Background: The prognosis of men and women with chronic coronary syndromes (CCS) remains ambiguous.

Aims: This study aimed to compare the clinical characteristics and 12‑month prognosis of women and men with CCS included in the prospective single‑center registry.

Methods: The study was based on the Prospective Registry of Stable Angina Management and Treatment (PRESAGE) including 11 021 patients with CCS hospitalized between 2006 and 2016 and subjected to coronary angiography. The composite endpoint included all‑cause death, nonfatal myocardial infarction, acute coronary syndrome with revascularization, unstable coronary artery disease, or stroke.

Results: Women were older than men (mean [SD] age, 66.6 [9] vs 63.5 [9.6] years; P < 0.001). Arterial hypertension (85.8% vs 79%; P < 0.001) and type 2 diabetes (38.2% vs 33.7%; P < 0.001) were more often diagnosed in women compared with men. Multivessel disease or left main disease were more frequent in men. Percutaneous coronary intervention and coronary artery bypass grafting were more often performed in men than in women (47.1% vs 36%, P < 0.001 and 10.6% vs 6.1%, P < 0.001, respectively). At 12‑month follow‑up, the composite endpoint was more frequently reached in men (7.4% vs 10.2%; P < 0.001), including death (3.3% vs 4.5%; P = 0.002). In multivariable analysis, sex was not an independent predictor of the composite endpoint (hazard ratio, 1.08; 95% CI, 0.89–1.31, P = 0.45).

Conclusions: Women and men with CCS differ in terms of the incidence of risk factors and revascularization treatments received. In men, a higher frequency of death and the composite endpoint was noted at 12‑month follow‑up. However, sex was not an independent predictor of patient outcomes at 12 months.