Vol 60, No 2 (2004)
Other
Published online: 2005-12-12
Effects of coronary artery by-pass grafting on haemostatic factors
DOI: 10.33963/v.kp.81953
Kardiol Pol 2004;60(2):118-122.
Abstract
Background: Atherogenesis is triggered by functional or structural endothelial injury which leads to humoral and secretion alterations. The haemostatic system plays a significant role in the development of atherosclerosis and its complications, especially acute coronary syndromes.
Aim: To assess the effects of coronary artery by-pass grafting (CABG) on some haemostatic factors in patients with stable coronary artery disease (CAD).
Methods: The study group consisted of 45 patients (11 females, 34 males, mean age 60.4±9.4 years, range 35-75 years). Endothelial function marker - von Willebrand factor (vWF), and thrombin generation parameters - thrombinantithrombin complexes (TAT) and prothrombin fragments - F1+2 were measured before as well as 3 days, 7 days and 3 months after CABG. The control group consisted of 33 healthy volunteers (17 females, 16 males, mean age 48.8±17.2 years).
Results: Serum concentration of vWF as well as TAT and F1+2 levels were significantly higher in the CABG group than in controls. Compared with baseline values, the vWF levels were significantly higher 3 and 7 days after CABG.
Conclusions: There is a hypercoagulability state in patients with CAD who undergo CABG. The use of extracoroporeal circulation causes a significant increase in the vWF level which suggests a marked endothelial injury caused by CABG procedure.
Aim: To assess the effects of coronary artery by-pass grafting (CABG) on some haemostatic factors in patients with stable coronary artery disease (CAD).
Methods: The study group consisted of 45 patients (11 females, 34 males, mean age 60.4±9.4 years, range 35-75 years). Endothelial function marker - von Willebrand factor (vWF), and thrombin generation parameters - thrombinantithrombin complexes (TAT) and prothrombin fragments - F1+2 were measured before as well as 3 days, 7 days and 3 months after CABG. The control group consisted of 33 healthy volunteers (17 females, 16 males, mean age 48.8±17.2 years).
Results: Serum concentration of vWF as well as TAT and F1+2 levels were significantly higher in the CABG group than in controls. Compared with baseline values, the vWF levels were significantly higher 3 and 7 days after CABG.
Conclusions: There is a hypercoagulability state in patients with CAD who undergo CABG. The use of extracoroporeal circulation causes a significant increase in the vWF level which suggests a marked endothelial injury caused by CABG procedure.
Keywords: cabg - haemostatic factors - endothelium
