Vol 69, No 4 (2011)
Reviews
Published online: 2011-04-26
Chronic inflammation in patients with acute coronary syndrome and chronic kidney disease
DOI: 10.33963/v.kp.79360
Kardiol Pol 2011;69(4):388-393.
Abstract
Chronic kidney disease is a worldwide growing problem in public health. It is a risk factor for complications in patients with
acute coronary syndrome (ACS). Diabetes, hypertension (hypertrophy and left ventricular failure), impaired fibrinolysis and
coagulation processes, as well as the rapid development of atherosclerosis (partly associated with chronic inflammation) are
responsible for higher prevalence of cardiovascular diseases in patients with chronic kidney disease. Inflammatory process of
unknown aetiology belongs to the so-called non-traditional risk factors in development of cardiovascular system diseases. It is
thought that this process is responsible for adverse remodelling of atherosclerosis plaque and its instability which causes
plaque rupture and as a result a coronary syndrome occurrence. Important inflammatory mediators, which take part in
pathogenesis of ACS, are acute phase proteins such as: C-reactive protein, adhesion molecules VCAM-1, ICAM-1, selectins,
plasma amyloid A, metalloproteinases, interleukins-1 and -6, tumour necrosis factor-a and vascular endothelial growth factor.
Kardiol Pol 2011; 69, 4: 388-393
Kardiol Pol 2011; 69, 4: 388-393
Keywords: chronic inflammationacute coronary syndromechronic kidney diseaserisk factors