open access
Assessment of choroid thickness by swept‑source optical coherence tomography (SS-OCT) in patients with posterior uveitis
Affiliations- Shroff Eye Centre, Kailash Colony, New Delhi, India
open access
Abstract
Background: This study aimed to measure the changes in choroid thickness using Swept-Source Optical Coherence Tomography (SS-OCT) after treatment of posterior uveitis along with changes in fundus auto-fluorescence pattern.
Material and methods: This prospective observational cohort study was conducted from December 2018 to May 2020, in which 32 eyes of 20 patients presenting in the out-patient department with a clinical diagnosis of posterior uveitis were enrolled. Best-corrected visual acuity (BCVA) by Snellen chart, intraocular pressure (IOP) Measurement using a non-contact tonometer, choroidal thickness by SS-OCT, and fundus imaging by Fundus Autofluorescence was done. All tests were done at baseline, first follow-up of 2 ± 1 weeks and the second follow-up of 6 ± 2 weeks. Data was compiled and analyzed.
Results: The mean age of patients was 31 ± 6.9 years with M:F of 3:1. During the second follow-up, with the healing of the lesions, there was a significant reduction in the choroidal thickness at all levels by SS-OCT (p < 0.05), with significant improvement in BCVA (0.05 vs. 0.14 vs. 0.31, p < 0.05). IOP increased significantly at the first follow-up to 17.31 from baseline (16.25) (p = 0.032). However, the rise at the second follow-up was not significant (17.03 vs. 16.25 at baseline, p = 0.15). On fundus autofluorescence, normal autofluorescence and hypofluorescence increased at the second follow-up of 6 weeks (p < 0.0001)
Conclusion: SS-OCT showed a significant decrease in the choroidal thickness at all levels during the follow-ups. The healing of the posterior uveitis lesions and fundus autofluorescence became normal simultaneously.
Abstract
Background: This study aimed to measure the changes in choroid thickness using Swept-Source Optical Coherence Tomography (SS-OCT) after treatment of posterior uveitis along with changes in fundus auto-fluorescence pattern.
Material and methods: This prospective observational cohort study was conducted from December 2018 to May 2020, in which 32 eyes of 20 patients presenting in the out-patient department with a clinical diagnosis of posterior uveitis were enrolled. Best-corrected visual acuity (BCVA) by Snellen chart, intraocular pressure (IOP) Measurement using a non-contact tonometer, choroidal thickness by SS-OCT, and fundus imaging by Fundus Autofluorescence was done. All tests were done at baseline, first follow-up of 2 ± 1 weeks and the second follow-up of 6 ± 2 weeks. Data was compiled and analyzed.
Results: The mean age of patients was 31 ± 6.9 years with M:F of 3:1. During the second follow-up, with the healing of the lesions, there was a significant reduction in the choroidal thickness at all levels by SS-OCT (p < 0.05), with significant improvement in BCVA (0.05 vs. 0.14 vs. 0.31, p < 0.05). IOP increased significantly at the first follow-up to 17.31 from baseline (16.25) (p = 0.032). However, the rise at the second follow-up was not significant (17.03 vs. 16.25 at baseline, p = 0.15). On fundus autofluorescence, normal autofluorescence and hypofluorescence increased at the second follow-up of 6 weeks (p < 0.0001)
Conclusion: SS-OCT showed a significant decrease in the choroidal thickness at all levels during the follow-ups. The healing of the posterior uveitis lesions and fundus autofluorescence became normal simultaneously.
Keywords
choroidal thickness; fundus autofluorescence; swept-source optical coherence tomography
About this articleTitle
Assessment of choroid thickness by swept‑source optical coherence tomography (SS-OCT) in patients with posterior uveitis
Journal
Issue
Vol 7 (2022): Continuous Publishing
Article type
Original paper
Pages
86-93
Published online
2022-05-20
Page views
4663
Article views/downloads
493
DOI
Bibliographic record
Ophthalmol J 2022;7:86-93.
Keywords
choroidal thickness
fundus autofluorescence
swept-source optical coherence tomography
Authors
Abhishek Agarwal
Shishir Narain
Charu Gupta
Priyanka Gupta
Daraius Shroff
Cyrus M. Shroff
References (22)- Vezzola D, Allegrini D, Borgia A, et al. Swept-source optical coherence tomography and optical coherence tomography angiography in acquired toxoplasmic chorioretinitis: a case report. J Med Case Rep. 2018; 12(1): 358.
- Kim M, Kim H, Kwon HJ, et al. Choroidal thickness in Behcet's uveitis: an enhanced depth imaging-optical coherence tomography and its association with angiographic changes. Invest Ophthalmol Vis Sci. 2013; 54(9): 6033–6039.
- Kishi S. Impact of swept source optical coherence tomography on ophthalmology. Taiwan J Ophthalmol. 2016; 6(2): 58–68.
- Samy A, Lightman S, Ismetova F, et al. Role of autofluorescence in inflammatory/infective diseases of the retina and choroid. J Ophthalmol. 2014; 2014: 418193.
- Gupta V, Al-Dhibi HA, Arevalo JF. Retinal imaging in uveitis. Saudi J Ophthalmol. 2014; 28(2): 95–103.
- Maruko I, Iida T, Sugano Y, et al. Subfoveal choroidal thickness after treatment of Vogt-Koyanagi-Harada disease. Retina. 2011; 31(3): 510–517.
- Copete S, Flores-Moreno I, Montero JA, et al. Direct comparison of spectral-domain and swept-source OCT in the measurement of choroidal thickness in normal eyes. Br J Ophthalmol. 2014; 98(3): 334–338.
- Adhi M, Liu JJ, Qavi AH, et al. Choroidal analysis in healthy eyes using swept-source optical coherence tomography compared to spectral domain optical coherence tomography. Am J Ophthalmol. 2014; 157(6): 1272–1281.e1.
- Bhayana AA, Kumar V, Tayade A, et al. Choroidal thickness in normal Indian eyes using swept-source optical coherence tomography. Indian J Ophthalmol. 2019; 67(2): 252–255.
- Rishi P, Akhtar Z, Agrawal R, et al. Choroidal thickness in normal Indian subjects using Swept source optical coherence tomography. PLoS One. 2018; 13(5): e0197457–55.
- Jaisankar D, Raman R, Sharma HR, et al. Choroidal and Retinal Anatomical Responses Following Systemic Corticosteroid Therapy in Vogt-Koyanagi-Harada Disease Using Swept-Source Optical Coherence Tomography. Ocul Immunol Inflamm. 2019; 27(2): 235–243.
- Koizumi H, Pozzoni MC, Spaide RF. Fundus autofluorescence in birdshot chorioretinopathy. Ophthalmology. 2008; 115(5): e15–e20.
- Haen SP, Spaide RF. Fundus autofluorescence in multifocal choroiditis and panuveitis. Am J Ophthalmol. 2008; 145(5): 847–853.
- Cardillo PF, Grosso A, Savini E. Fundus autofluorescence in serpiginous choroiditis. Graefes Arch Clin Exp Ophthalmol. 2009; 247(2): 179–85.
- Ayata A, Dogru S, Senol MG, et al. Autofluorescence findings in Vogt-Koyanagi-Harada disease. Eur J Ophthalmol. 2009; 19(6): 1094–1097.
- Koizumi H, Maruyama K, Kinoshita S. Blue light and near-infrared fundus autofluorescence in acute Vogt-Koyanagi-Harada disease. Br J Ophthalmol. 2010; 94(11): 1499–1505.
- Yeh S, Forooghian F, Wong WT, et al. Fundus autofluorescence imaging of the white dot syndromes. Arch Ophthalmol. 2010; 128(1): 46–56.
- Spaide RF. Collateral damage in acute zonal occult outer retinopathy. Am J Ophthalmol. 2004; 138(5): 887–889.
- Furino C, Boscia F, Cardascia N, et al. Fundus autofluorescence and multiple evanescent white dot syndrome. Retina. 2009; 29(1): 60–63.
- Giuliari G, Hinkle DM, Foster CS. The spectrum of fundus autofluorescence findings in birdshot chorioretinopathy. J Ophthalmol. 2009; 2009: 567693.
- Bansal R, Basu S, Gupta A, et al. Imaging in tuberculosis-associated uveitis. Indian J Ophthalmol. 2017; 65(4): 264–270.
- Ishikawa S, Taguchi M, Muraoka T, et al. Changes in subfoveal choroidal thickness associated with uveitis activity in patients with Behçet's disease. Br J Ophthalmol. 2014; 98(11): 1508–1513.