open access

Vol 7 (2022): Continuous Publishing
Case report
Published online: 2022-03-17
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Trichoadenoma of the upper eyelid: case report and literature review

Carlos Izquierdo-Rodriguez12, Emilio Dorronzoro-Ramirez3, Santiago Nieto-Llanos12
·
Ophthalmol J 2022;7:1-5.
Affiliations
  1. Henares University Hospital, Spain
  2. Facultad de Ciencias de la Salud, Universidad Francisco de Vitoria, Pozuelo de Alarcón, Spain
  3. Sanitas La Moraleja Hospital, Madrid, Spain

open access

Vol 7 (2022): Continuous Publishing
CASE REPORTS
Published online: 2022-03-17

Abstract

Background: Trichoadenoma of Nikolowski is a rare and benign tumor of the hair follicle. It was first described in 1958. The clinical appearance of trichoadenoma can be confused with basal cell carcinoma, and a differential diagnosis must be made with this entity and with other benign lesions such as epidermal cyst, seborrheic keratosis, actinic keratosis, and more exceptionally with comedo.

Case presentation: We report a case of a 45-year-old woman with a pigmented lesion in the left eyelid mimicking comedo. Histopathology study showed lesions containing keratinous cysts surrounded by lymphocytic components in the dermis and hair shaft among the cystic keratin, which is unusual in these tumors. The lesions were diagnosed as trichoadenoma.

Conclusion: We suggest that all excised eyelid lesions be sent to histopathological study.

Abstract

Background: Trichoadenoma of Nikolowski is a rare and benign tumor of the hair follicle. It was first described in 1958. The clinical appearance of trichoadenoma can be confused with basal cell carcinoma, and a differential diagnosis must be made with this entity and with other benign lesions such as epidermal cyst, seborrheic keratosis, actinic keratosis, and more exceptionally with comedo.

Case presentation: We report a case of a 45-year-old woman with a pigmented lesion in the left eyelid mimicking comedo. Histopathology study showed lesions containing keratinous cysts surrounded by lymphocytic components in the dermis and hair shaft among the cystic keratin, which is unusual in these tumors. The lesions were diagnosed as trichoadenoma.

Conclusion: We suggest that all excised eyelid lesions be sent to histopathological study.

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Keywords

trichoadenoma; hair follicle tumor; adnexal tumor

About this article
Title

Trichoadenoma of the upper eyelid: case report and literature review

Journal

Ophthalmology Journal

Issue

Vol 7 (2022): Continuous Publishing

Article type

Case report

Pages

1-5

Published online

2022-03-17

Page views

4885

Article views/downloads

553

DOI

10.5603/OJ.2022.0001

Bibliographic record

Ophthalmol J 2022;7:1-5.

Keywords

trichoadenoma
hair follicle tumor
adnexal tumor

Authors

Carlos Izquierdo-Rodriguez
Emilio Dorronzoro-Ramirez
Santiago Nieto-Llanos

References (16)
  1. Nikolowski W. [Trichoadenoma (organoid follicular hamartoma)]. Arch Klin Exp Dermatol. 1958; 207(1): 34–45.
  2. Shimanovich I, Krahl D, Rose C. Trichoadenoma of Nikolowski is a distinct neoplasm within the spectrum of follicular tumors. J Am Acad Dermatol. 2010; 62(2): 277–283.
  3. Sieron J, Thein T, Pirsig W, et al. [The Nikolowski trichoadenoma: a rare tumor of the ENT area]. Laryngorhinootologie. 1993; 72(3): 140–142.
  4. Mahajan SR, Shah CA, Shah MM, et al. A rare case of trichoadenoma over the vulva. Indian J Sex Transm Dis AIDS. 2015; 36(1): 83–85.
  5. Pavithran K, Vijyalakshmy A. Trichoadenoma of Nikolowsky. Ind J Dermatol. 1996; 41(3): 106–07.
  6. Shields J, Shields C, Eagle R. Trichoadenoma of the eyelid. Am J Ophthalmol . 1998; 126(6): 846–848.
  7. Lever JF, Servat JJ, Nesi-Eloff F, et al. Trichoadenoma of an eyelid in an adult mimicking sebaceous cell carcinoma. Ophthalmic Plast Reconstr Surg. 2012; 28(4): e101–e102.
  8. Cheng H, Deng J. Trichoadenoma of the Upper Eyelid Mimicking Comedo-Like Lesions. Ophthalmic Plast Reconstr Surg. 2019; 35(4): e94–e95.
  9. Shields JA, Shields CL. Hair Follicle Tumors. In: Shields JA, Shields CL. ed. Atlas of Eyelid and Conjunctival Tumors. Lippincot Williams @ Wilkins, Philadelphia 1999: 66–67.
  10. Huet P, Jegou MH, Bourlond F, et al. [Anatomoclinical and dermatoscopic study of trichoadenoma]. Ann Dermatol Venereol. 2020; 147(5): 334–339.
  11. Rahbari H, Mehregan A, Pinkus H. Trichoadenoma of Nikolowski. J Cutan Pathol. 1977; 4(2): 90–98.
  12. Nikolowski W. [Trichoadenoma]. Z Hautzkr. 1978; 53: 87–90.
  13. Hey A, Rockelein G, Grouls V. [The so-called trichoadenoma (Nikolowski)]. Pathologe. 1987; 8(1): 48–51.
  14. Jaqueti G, Requena L, Sánchez Yus E. Verrucous trichoadenoma. J Cutan Pathol. 1989; 16(3): 145–148.
  15. Reibold R, Undeutsch W, Fleiner J. [Trichoadenoma of Nikolowski--review of four decades and seven new cases]. Hautarzt. 1998; 49(12): 925–928.
  16. Kurokawa I, Mizutani H, Nishijima S, et al. Trichoadenoma: cytokeratin expression suggesting differentiation towards the follicular infundibulum and follicular bulge regions. Br J Dermatol. 2005; 153(5): 1084–1086.

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