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Bilateral diffuse uveal melanocytic proliferation secondary to acute lymphoblastic leukemia: a case report
Affiliations- Department of Pediatric Oncology, King Hussein Cancer Center (KHCC), Amman, Jordan
- Department of Surgery/Ophthalmology, King Hussein Cancer Center (KHCC), Amman, Jordan
- Department of General Ophthalmology, Medical University of Lublin, Poland
open access
Abstract
Background: Bilateral diffuse uveal melanocytic proliferation (BDUMP) is a very rare paraneoplastic syndrome that might present with carcinoma. We present a case of an atypical BDUMP secondary to acute B-cell lymphoblastic leukemia (ALL) and report management outcomes at six months follow-up.
Case presentation: A 14-year-old female patient with known B-cell ALL presented with blurred vision and headache. Ophthalmological examination revealed new-onset, multiple, round, and pigmented choroidal lesions. Based on the clinical presentation, the diagnosis of BDUMP was suspected. Screening for second malignancies was negative. After nine sessions of plasmapheresis, ophthalmologic examination showed stable, non-progressive retinal lesions with maintained vision and absence of retinal detachment or cataract.
Conclusion: This was a rare case of BDUMP in a young patient with a known case of ALL.
Abstract
Background: Bilateral diffuse uveal melanocytic proliferation (BDUMP) is a very rare paraneoplastic syndrome that might present with carcinoma. We present a case of an atypical BDUMP secondary to acute B-cell lymphoblastic leukemia (ALL) and report management outcomes at six months follow-up.
Case presentation: A 14-year-old female patient with known B-cell ALL presented with blurred vision and headache. Ophthalmological examination revealed new-onset, multiple, round, and pigmented choroidal lesions. Based on the clinical presentation, the diagnosis of BDUMP was suspected. Screening for second malignancies was negative. After nine sessions of plasmapheresis, ophthalmologic examination showed stable, non-progressive retinal lesions with maintained vision and absence of retinal detachment or cataract.
Conclusion: This was a rare case of BDUMP in a young patient with a known case of ALL.
Keywords
acute lymphoblastic leukemia; bilateral diffuse uveal melanocytic proliferation; retina
About this articleTitle
Bilateral diffuse uveal melanocytic proliferation secondary to acute lymphoblastic leukemia: a case report
Journal
Issue
Vol 6 (2021): Continuous Publishing
Article type
Case report
Pages
270-273
Published online
2021-12-30
Page views
5462
Article views/downloads
311
DOI
Bibliographic record
Ophthalmol J 2021;6:270-273.
Keywords
acute lymphoblastic leukemia
bilateral diffuse uveal melanocytic proliferation
retina
Authors
Muhanad Alshathly
Mayada Abu Shanap
Yacoub A. Yousef
Mario Damiano Toro
Reham Shehada
Robert Rejdak
Katarzyna Nowomiejska
Iyad Sultan
Mona Mohammad
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