open access
Retinal nerve fiber layer defects in the presence of a physiological cup to disc ratio — a case series
- Collective Innovations Colombia, Cali, Colombia
- Pontificia Universidad Javeriana, Cali, Colombia
- GSR Medical Center, Cali, Colombia
- GSR International, United States
- UT Health San Antonio, San Antonio, United States
- University of Tennessee Health Science Center
open access
Abstract
Retinal nerve fiber layer (RNFL) defects are one of the earliest signs of glaucoma. Typically, these RNFL defects are associated with an increased cup/disc ratio and a thinning of the neuroretinal rim. When the cup/disc ratio is within normal limits, the observer can misdiagnose subtle RNFL defects and lead to an essential delay in diagnosis, which has negative visual consequences in these patients. We present a case series report addressing RNFL defects with a physiological cup/disc ratio.
Abstract
Retinal nerve fiber layer (RNFL) defects are one of the earliest signs of glaucoma. Typically, these RNFL defects are associated with an increased cup/disc ratio and a thinning of the neuroretinal rim. When the cup/disc ratio is within normal limits, the observer can misdiagnose subtle RNFL defects and lead to an essential delay in diagnosis, which has negative visual consequences in these patients. We present a case series report addressing RNFL defects with a physiological cup/disc ratio.
Keywords
glaucoma; retinal nerve fiber defects; cup/disc ratio
Title
Retinal nerve fiber layer defects in the presence of a physiological cup to disc ratio — a case series
Journal
Issue
Vol 6 (2021): Continuous Publishing
Article type
Case report
Pages
258-264
Published online
2021-12-30
Page views
5712
Article views/downloads
595
DOI
Bibliographic record
Ophthalmol J 2021;6:258-264.
Keywords
glaucoma
retinal nerve fiber defects
cup/disc ratio
Authors
Carlos Eduardo Rivera
Juan Carlos Aristizabal
Edgar Muñoz
Ankur Seth
- Kwon YH, et al. Primary Open-Angle Glaucoma. N Engl J Med. 2009; 360(11): 1113–1124.
- Hood DC, Kardon RH. A framework for comparing structural and functional measures of glaucomatous damage. Prog Retin Eye Res. 2007; 26(6): 688–710.
- Inzelberg R, Ramirez JA, Nisipeanu P, et al. Retinal nerve fiber layer thinning in Parkinson disease. Vision Res. 2004; 44(24): 2793–2797.
- Paquet C, Boissonnot M, Roger F, et al. Abnormal retinal thickness in patients with mild cognitive impairment and Alzheimer's disease. Neurosci Lett. 2007; 420(2): 97–99.
- Hoyt WF, Schlicke B, Eckelhoff RJ. Fundoscopic appearance of a nerve-fibre-bundle defect. Br J Ophthalmol. 1972; 56(8): 577–583.
- Quigley HA. Examination of the retinal nerve fiber layer in the recognition of early glaucoma damage. Trans Am Ophthalmol Soc. 1986; 84: 920–966.
- Radius RL, Anderson DR. The histology of retinal nerve fiber layer bundles and bundle defects. Arch Ophthalmol. 1979; 97(5): 948–950.
- Airaksinen P, Drance S, Douglas G, et al. Diffuse and Localized Nerve Fiber Loss in Glaucoma. Am J Ophthalmol. 1984; 98(5): 566–571.
- Hoyt WF, Schlicke B, Eckelhoff RJ. Fundoscopic appearance of a nerve-fibre-bundle defect. Br J Ophthalmol. 1972; 56(8): 577–583.
- Tuulonen A, Lehtola J, Airaksinen P. Nerve Fiber Layer Defects with Normal Visual Fields. Ophthalmology. 1993; 100(5): 587–598.
- Jonas JB, Schiro D. Localized retinal nerve fiber layer defects in nonglaucomatous optic nerve atrophy. Graefes Arch Clin Exp Ophthalmol. 1994; 232(12): 759–760.
- Hwang YH, Kim YY, Kim HKi, et al. Ability of cirrus high-definition spectral-domain optical coherence tomography clock-hour, deviation, and thickness maps in detecting photographic retinal nerve fiber layer abnormalities. Ophthalmology. 2013; 120(7): 1380–1387.
- Foster PJ, Buhrmann R, Quigley HA, et al. The definition and classification of glaucoma in prevalence surveys. Br J Ophthalmol. 2002; 86(2): 238–242.