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Uveitis presenting with iris bombe in a patient with HIV: the importance of multi-disciplinary management — a case study
, 2, 2
Affiliations- Barts Health NHS Trust, Academic Foundation Program, Royal London Hospital, London, United Kingdom
- Imperial College Healthcare NHS Trust, London, United Kingdom
open access
Abstract
This case study concerns a 53-year-old female presenting to an eye-hospital in London with uveitis, on a background of well-controlled HIV. After investigation, no cause for the uveitis was found other than the HIV itself, and the patient was treated with immunosuppressants. Because of the nature of her underlying HIV infection, help was sought from HIV specialists, who gave advice on the management, including alteration of corticosteroid dosing due to the risk of drug-interactions between her uveitis and HIV treatments. Of particular concern was the risk of cytochrome P450 3A inhibition by cobicistat and the potential for iatrogenic Cushing syndrome through elevated steroid doses.
This case is used as an example to highlight the importance of the multi-disciplinary team in the management of
complex conditions, as well as to add to the literature in support of the HIV virus itself as a cause of uveitis.
Abstract
This case study concerns a 53-year-old female presenting to an eye-hospital in London with uveitis, on a background of well-controlled HIV. After investigation, no cause for the uveitis was found other than the HIV itself, and the patient was treated with immunosuppressants. Because of the nature of her underlying HIV infection, help was sought from HIV specialists, who gave advice on the management, including alteration of corticosteroid dosing due to the risk of drug-interactions between her uveitis and HIV treatments. Of particular concern was the risk of cytochrome P450 3A inhibition by cobicistat and the potential for iatrogenic Cushing syndrome through elevated steroid doses.
This case is used as an example to highlight the importance of the multi-disciplinary team in the management of
complex conditions, as well as to add to the literature in support of the HIV virus itself as a cause of uveitis.
Keywords
uveitis; HIV; iris bombe; multi-disciplinary; inflammation
About this articleTitle
Uveitis presenting with iris bombe in a patient with HIV: the importance of multi-disciplinary management — a case study
Journal
Issue
Vol 5 (2020): Continuous Publishing
Article type
Case report
Pages
29-32
Published online
2020-07-09
Page views
605
Article views/downloads
709
DOI
Bibliographic record
Ophthalmol J 2020;5:29-32.
Keywords
uveitis
HIV
iris bombe
multi-disciplinary
inflammation
Authors
Thomas RP Taylor
Neil Shah
Rashmi Akshikar
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