open access

Vol 3, No 1 (2018)
Case report
Published online: 2018-07-20
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Visual rehabilitation training in a patient with large central scotoma due to Leber’s hereditary optic neuropathy

Agnieszka Kiszka1, Dominika Nowakowska, Katarzyna Nowomiejska1, Katarzyna Tońska2, Robert Rejdak13
·
Ophthalmol J 2018;3(1):21-27.
Affiliations
  1. Department of General Ophthalmology, Medical University of Lublin, Poland, Chmielna 1, 20-080 Lublin, Poland
  2. Institute of Genetics and Biotechnology, University of Warsaw, Warsaw, Poland, ul. Pawińskiego 5a, 02-106 Warsaw, Poland
  3. Department of Experimental Pharmacology, Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland

open access

Vol 3, No 1 (2018)
CASE REPORTS
Published online: 2018-07-20

Abstract

Background. Leber’s hereditary optic neuropathy (LHON) is a disease associated with pathogenetic mutations of mitochondrial DNA which affects predominantly young adult males and leads to loss of central vision, low visual acuity and unstable fixation. The purpose of this study was to allow the patient to establish the best possible fixation in the best area of retinal sensitivity in LHON patient with central scotoma.

Methods. A 17 years old patient with confirmed mitochondrial LHON 11778G > A mutation was included in the study. The patient underwent 16 visual rehabilitation sessions — two for each of 8 weeks using the training module available in the equipment — MAIA microperimeter. Visual acuity and standrad microperimetry examination were performed before and 8 weeks period of training. To measure the fixation stability with MAIA microperimeter, P1, P2 and Bivariate Contour Ellipse Area (BCEA) parameters were used.

Results. Visual acuity of the trained better eye was 0.08 at the baseline versus 0.063 after 8 weeks training. Fixation stability parameter was P1-21%, P2-64% at the first session versus P1-60%, P2-90% at the last session. BCEA values 29.2°˛ before and 14.2°˛ after training, respectively.

Conclusions. Visual training via microperimetry could potentially be a method that improves the fixation stability in patients with LHON.  

Abstract

Background. Leber’s hereditary optic neuropathy (LHON) is a disease associated with pathogenetic mutations of mitochondrial DNA which affects predominantly young adult males and leads to loss of central vision, low visual acuity and unstable fixation. The purpose of this study was to allow the patient to establish the best possible fixation in the best area of retinal sensitivity in LHON patient with central scotoma.

Methods. A 17 years old patient with confirmed mitochondrial LHON 11778G > A mutation was included in the study. The patient underwent 16 visual rehabilitation sessions — two for each of 8 weeks using the training module available in the equipment — MAIA microperimeter. Visual acuity and standrad microperimetry examination were performed before and 8 weeks period of training. To measure the fixation stability with MAIA microperimeter, P1, P2 and Bivariate Contour Ellipse Area (BCEA) parameters were used.

Results. Visual acuity of the trained better eye was 0.08 at the baseline versus 0.063 after 8 weeks training. Fixation stability parameter was P1-21%, P2-64% at the first session versus P1-60%, P2-90% at the last session. BCEA values 29.2°˛ before and 14.2°˛ after training, respectively.

Conclusions. Visual training via microperimetry could potentially be a method that improves the fixation stability in patients with LHON.  

Get Citation

Keywords

Leber’s hereditary optic neuropathy, eccentric viewing, eye-fixation training, microperimetry

About this article
Title

Visual rehabilitation training in a patient with large central scotoma due to Leber’s hereditary optic neuropathy

Journal

Ophthalmology Journal

Issue

Vol 3, No 1 (2018)

Article type

Case report

Pages

21-27

Published online

2018-07-20

Page views

770

Article views/downloads

815

DOI

10.5603/OJ.2018.0029

Bibliographic record

Ophthalmol J 2018;3(1):21-27.

Keywords

Leber’s hereditary optic neuropathy
eccentric viewing
eye-fixation training
microperimetry

Authors

Agnieszka Kiszka
Dominika Nowakowska
Katarzyna Nowomiejska
Katarzyna Tońska
Robert Rejdak

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