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Genetic association of apolipoprotein E with optic disc size
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Abstract
INTRODUCTION. The purpose of this clinical non-interventional cross-sectional study was to evaluate the role of apolipoprotein E (ApoE) gene alleles (e2, e3, e4) in the determination of optic disc size.
MATERIALS AND METHODS. In 32 normal controls, 54 patients with ocular hypertension (OHT), and 96 patients with primary open-angle the optic disc size was determined by planimetry using 15° colour stereo photographs. In all individuals ApoE genotyping was performed.
RESULTS. The size of the optic disc was significantly different between subjects with e3e2, e3e3, and e4e3 allele (Kruskal-Wallis-test, Chi-Square: 6.95, p = 0.031; 2.39, 2.77, and 2.78 mm2, respectively).
CONCLUSIONS. The results suggest that ApoE gene alleles are associated with optic disc size. ApoE may act as a modulator gene for optic disc morphogenesis.
Abstract
INTRODUCTION. The purpose of this clinical non-interventional cross-sectional study was to evaluate the role of apolipoprotein E (ApoE) gene alleles (e2, e3, e4) in the determination of optic disc size.
MATERIALS AND METHODS. In 32 normal controls, 54 patients with ocular hypertension (OHT), and 96 patients with primary open-angle the optic disc size was determined by planimetry using 15° colour stereo photographs. In all individuals ApoE genotyping was performed.
RESULTS. The size of the optic disc was significantly different between subjects with e3e2, e3e3, and e4e3 allele (Kruskal-Wallis-test, Chi-Square: 6.95, p = 0.031; 2.39, 2.77, and 2.78 mm2, respectively).
CONCLUSIONS. The results suggest that ApoE gene alleles are associated with optic disc size. ApoE may act as a modulator gene for optic disc morphogenesis.
Keywords
apolipoprotein E, optic disc size, ApoE gene alleles
About this articleTitle
Genetic association of apolipoprotein E with optic disc size
Journal
Issue
Article type
Original paper
Pages
59-61
Published online
2016-07-07
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631
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715
DOI
Bibliographic record
Ophthalmol J 2016;1(2):59-61.
Keywords
apolipoprotein E
optic disc size
ApoE gene alleles
Authors
Anselm G.M. Jünemann
Udo Reulbach
Stefan Bleich
Johannes Kornhuber
Katarzyna Nowomiejska
Joanna Moneta-Wielgos
Robert Rejdak