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Quantitative evaluation of anterior chamber parameters using anterior segment optical coherence tomography in primary angle closure mechanisms in Caucasian eyes
Affiliations- Department of Diagnostics and Microsurgery of Glaucoma, Medical University of Lublin, Poland
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Abstract
BACKGROUND: The purpose of this study was to evaluate different mechanisms of primary angle closure disease (PACD) and quantify anterior chamber parameters in these mechanisms using anterior segment optical coherence tomography (ASOCT) in a Caucasian population.
DESIGN: Hospital-based cross-sectional observational study/Clinic based study.
PARTICIPANTS: 144 eyes (73 patients) with newly diagnosed primary angle closure disease (PACD), classified into three subtypes: primary angle closure suspect (PACS), primary angle closure (PAC), and primary angle closure glaucoma (PACG), were enrolled to the study.
MATERIAL AND METHODS: Participants underwent ASOCT (SS-1000 CASIA, Tomey Corporation, Nagoya, Japan) under the same standardized dark room conditions. ASOCT images were categorized into one of 4 groups based on the angle-closure mechanisms: pupillary block (PB), plateau iris configuration (PIC), thick peripheral iris (TPI), and large lens vault (LLV). Anterior chamber depth (ACD), anterior chamber area (ACA), anterior chamber volume (ACV), anterior chamber width (ACW), iris area (IA), iris curvature (IC), iris curvature area (ICA), iris thickness (IT750, IT2000), lens vault (LV), pupil diameter (PD), angle opening distance (AOD500, AOD750), angle recess area (ARA 500, ARA750), trabecular iris angle (TIA500, TIA750) and trabecular iris space area (TISA500, TISA750) were determined using 360o SS-OCT viewer software (version 5.0, Tomey, Nagoya, Japan).
RESULTS: Among 144 examined eyes, 83 eyes (57.6%) were classified as PB, 42 eyes (29.2%) as PIC, 14 eyes (9.7%) as TPI, and 5 eyes (3.5%) as LLV. 73.6% had a single underlying PAC mechanism, and the rest had more than one (combined mechanism) of PAC. Anterior chamber parameters (ACD, ACA, ACV) were the highest in the PIC group and the lowest in the LLV group. Angle parameters (AOD 500, AOD 750, TIA 750; SSAngle 500; SSAngle 750) showed the strongest relevance and were the highest in the PIC group and the lowest in the TPI group. LV was the greatest in the LLV and the lowest in the TPI and PIC groups. Axial length (AL) was the largest in PIC, followed by PB, and the smallest in the LLV group.
CONCLUSION: Anterior chamber and anterior chamber angle parameters showed significant differences between the four angle closure mechanisms. Identifying the angle closure mechanisms could lead to better disease management by individualizing the treatment.
Abstract
BACKGROUND: The purpose of this study was to evaluate different mechanisms of primary angle closure disease (PACD) and quantify anterior chamber parameters in these mechanisms using anterior segment optical coherence tomography (ASOCT) in a Caucasian population.
DESIGN: Hospital-based cross-sectional observational study/Clinic based study.
PARTICIPANTS: 144 eyes (73 patients) with newly diagnosed primary angle closure disease (PACD), classified into three subtypes: primary angle closure suspect (PACS), primary angle closure (PAC), and primary angle closure glaucoma (PACG), were enrolled to the study.
MATERIAL AND METHODS: Participants underwent ASOCT (SS-1000 CASIA, Tomey Corporation, Nagoya, Japan) under the same standardized dark room conditions. ASOCT images were categorized into one of 4 groups based on the angle-closure mechanisms: pupillary block (PB), plateau iris configuration (PIC), thick peripheral iris (TPI), and large lens vault (LLV). Anterior chamber depth (ACD), anterior chamber area (ACA), anterior chamber volume (ACV), anterior chamber width (ACW), iris area (IA), iris curvature (IC), iris curvature area (ICA), iris thickness (IT750, IT2000), lens vault (LV), pupil diameter (PD), angle opening distance (AOD500, AOD750), angle recess area (ARA 500, ARA750), trabecular iris angle (TIA500, TIA750) and trabecular iris space area (TISA500, TISA750) were determined using 360o SS-OCT viewer software (version 5.0, Tomey, Nagoya, Japan).
RESULTS: Among 144 examined eyes, 83 eyes (57.6%) were classified as PB, 42 eyes (29.2%) as PIC, 14 eyes (9.7%) as TPI, and 5 eyes (3.5%) as LLV. 73.6% had a single underlying PAC mechanism, and the rest had more than one (combined mechanism) of PAC. Anterior chamber parameters (ACD, ACA, ACV) were the highest in the PIC group and the lowest in the LLV group. Angle parameters (AOD 500, AOD 750, TIA 750; SSAngle 500; SSAngle 750) showed the strongest relevance and were the highest in the PIC group and the lowest in the TPI group. LV was the greatest in the LLV and the lowest in the TPI and PIC groups. Axial length (AL) was the largest in PIC, followed by PB, and the smallest in the LLV group.
CONCLUSION: Anterior chamber and anterior chamber angle parameters showed significant differences between the four angle closure mechanisms. Identifying the angle closure mechanisms could lead to better disease management by individualizing the treatment.
Keywords
anterior chamber parameters; anterior chamber angle parameters; anterior segment optical coherence tomography; ASOCT; primary angle closure suspects; PACS; primary angle closure; PAC; primary angle closure glaucoma; PACG; angle closure mechanisms
About this articleTitle
Quantitative evaluation of anterior chamber parameters using anterior segment optical coherence tomography in primary angle closure mechanisms in Caucasian eyes
Journal
Issue
Vol 9 (2024): Continuous Publishing
Article type
Original paper
Pages
68-76
Published online
2024-03-28
Page views
67
Article views/downloads
34
DOI
10.5603/oj.98652
Bibliographic record
Ophthalmol J 2024;9:68-76.
Keywords
anterior chamber parameters
anterior chamber angle parameters
anterior segment optical coherence tomography
ASOCT
primary angle closure suspects
PACS
primary angle closure
PAC
primary angle closure glaucoma
PACG
angle closure mechanisms
Authors
Andrzej Sawicki
Agnieszka Wilkos-Kuc
Tomasz Żarnowski
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