open access

Vol 8 (2023): Continuous Publishing
Review paper
Published online: 2023-11-16
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Intense pulsed light treatment in meibomian gland dysfunction

Monika Senterkiewicz12, Damian Jaworski12, Bartłomiej Kałużny12
·
Ophthalmol J 2023;8:101-106.
Affiliations
  1. Division of Ophthalmology and Optometry, Department of Ohthalmology, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland
  2. Oftalmika Eye Hospital, Bydgoszcz, Poland, Poland

open access

Vol 8 (2023): Continuous Publishing
REVIEW
Published online: 2023-11-16

Abstract

Dry eye disease (DED) associated with meibomian gland dysfunction (MGD) is a chronic and progressive disease that can cause numerous eye symptoms, such as discomfort, irritation, stabbing, and vision disturbances. Previously used treatment methods are insufficient for some patients. The article describes the indications, method of performing, mechanisms of action, and effectiveness of intense pulsed light (IPL) regarding available literature. The technique involves using a series of impulses of non-coherent, polychromatic broad-bandwidth wavelengths in the periorbital area to the skin around the eyes and eyelids. Numerous studies have shown the effectiveness of IPL for MGD, a decrease in symptoms connected with DED assessed by Ocular Surface Disease Index (OSDI) questionnaire, an increased tear break-up time (TBUT), and improvement of meibomian glands function indicators.

Abstract

Dry eye disease (DED) associated with meibomian gland dysfunction (MGD) is a chronic and progressive disease that can cause numerous eye symptoms, such as discomfort, irritation, stabbing, and vision disturbances. Previously used treatment methods are insufficient for some patients. The article describes the indications, method of performing, mechanisms of action, and effectiveness of intense pulsed light (IPL) regarding available literature. The technique involves using a series of impulses of non-coherent, polychromatic broad-bandwidth wavelengths in the periorbital area to the skin around the eyes and eyelids. Numerous studies have shown the effectiveness of IPL for MGD, a decrease in symptoms connected with DED assessed by Ocular Surface Disease Index (OSDI) questionnaire, an increased tear break-up time (TBUT), and improvement of meibomian glands function indicators.

Get Citation

Keywords

intense pulsed light therapy; meibomian gland dysfunction; dry eye disease; treatment

About this article
Title

Intense pulsed light treatment in meibomian gland dysfunction

Journal

Ophthalmology Journal

Issue

Vol 8 (2023): Continuous Publishing

Article type

Review paper

Pages

101-106

Published online

2023-11-16

Page views

317

Article views/downloads

183

DOI

10.5603/oj.94866

Bibliographic record

Ophthalmol J 2023;8:101-106.

Keywords

intense pulsed light therapy
meibomian gland dysfunction
dry eye disease
treatment

Authors

Monika Senterkiewicz
Damian Jaworski
Bartłomiej Kałużny

References (30)
  1. Craig JP, Nichols KK, Akpek EK, et al. TFOS DEWS II Definition and Classification Report. Ocul Surf. 2017; 15(3): 276–283.
  2. The epidemiology of dry eye disease: report of the Epidemiology Subcommittee of the International Dry Eye WorkShop (2007). Ocul Surf. 2007; 5(2): 93–107.
  3. Nichols KK, Foulks GN, Bron AJ, et al. The international workshop on meibomian gland dysfunction: executive summary. Invest Ophthalmol Vis Sci. 2011; 52(4): 1922–1929.
  4. Knop E, Knop N, Millar T, et al. The international workshop on meibomian gland dysfunction: report of the subcommittee on anatomy, physiology, and pathophysiology of the meibomian gland. Invest Ophthalmol Vis Sci. 2011; 52(4): 1938–1978.
  5. Foulks GN, Nichols KK, Bron AJ, et al. Improving awareness, identification, and management of meibomian gland dysfunction. Ophthalmology. 2012; 119(10 Suppl): S1–12.
  6. Lam PY, Shih KCo, Fong PY, et al. A Review on Evidence-Based Treatments for Meibomian Gland Dysfunction. Eye Contact Lens. 2020; 46(1): 3–16.
  7. Gupta PK, Vora GK, Matossian C, et al. Intense pulsed light therapy for the treatment of evaporative dry eye disease. Curr Opin Ophthalmol. 2015; 26(4): 314–318.
  8. Baudouin C, Messmer EM, Aragona P, et al. Revisiting the vicious circle of dry eye disease: a focus on the pathophysiology of meibomian gland dysfunction. Br J Ophthalmol. 2016; 100(3): 300–306.
  9. Toyos R, McGill W, Briscoe D. Intense pulsed light treatment for dry eye disease due to meibomian gland dysfunction; a 3-year retrospective study. Photomed Laser Surg. 2015; 33(1): 41–46.
  10. Dell SJ. Intense pulsed light for evaporative dry eye disease. Clin Ophthalmol. 2017; 11: 1167–1173.
  11. Schroeter CA, Haaf-von Below S, Neumann HAM. Effective treatment of rosacea using intense pulsed light systems. Dermatol Surg. 2005; 31(10): 1285–1289.
  12. Liu R, Rong B, Tu P, et al. Analysis of Cytokine Levels in Tears and Clinical Correlations After Intense Pulsed Light Treating Meibomian Gland Dysfunction. Am J Ophthalmol. 2017; 183: 81–90.
  13. Helbig D, Simon JC, Paasch U. Epidermal and dermal changes in response to various skin rejuvenation methods. Int J Cosmet Sci. 2010; 32(6): 458–469.
  14. Yin Y, Liu N, Gong L, et al. Changes in the Meibomian Gland After Exposure to Intense Pulsed Light in Meibomian Gland Dysfunction (MGD) Patients. Curr Eye Res. 2018; 43(3): 308–313.
  15. Irvine J, Chong SuL, Amirjani N, et al. Double-blind randomized controlled trial of low-level laser therapy in carpal tunnel syndrome. Muscle Nerve. 2004; 30(2): 182–187.
  16. Cao Y, Huo R, Feng Y, et al. Effects of intense pulsed light on the biological properties and ultrastructure of skin dermal fibroblasts: potential roles in photoaging. Photomed Laser Surg. 2011; 29(5): 327–332.
  17. Farrell HP, Garvey M, Cormican M, et al. Investigation of critical inter-related factors affecting the efficacy of pulsed light for inactivating clinically relevant bacterial pathogens. J Appl Microbiol. 2010; 108(5): 1494–1508.
  18. Prieto VG, Sadick NS, Lloreta J, et al. Effects of intense pulsed light on sun-damaged human skin, routine, and ultrastructural analysis. Lasers Surg Med. 2002; 30(2): 82–85.
  19. Jiang X, Yuan H, Zhang M, et al. The Efficacy and Safety of New-Generation Intense Pulsed Light in the Treatment of Meibomian Gland Dysfunction-Related Dry Eye: A Multicenter, Randomized, Patients-Blind, Parallel-Control, Non-Inferiority Clinical Trial. Ophthalmol Ther. 2022; 11(5): 1895–1912.
  20. Pazo EE, Huang He, Fan Q, et al. Intense Pulse Light for Treating Post-LASIK Refractory Dry Eye. Photobiomodul Photomed Laser Surg. 2021; 39(3): 155–163.
  21. Xue AL, Wang MTM, Ormonde SE, et al. Randomised double-masked placebo-controlled trial of the cumulative treatment efficacy profile of intense pulsed light therapy for meibomian gland dysfunction. Ocul Surf. 2020; 18(2): 286–297.
  22. Wladis EJ, Aakalu VK, Foster JA, et al. Intense Pulsed Light for Meibomian Gland Disease: A Report by the American Academy of Ophthalmology. Ophthalmology. 2020; 127(9): 1227–1233.
  23. Liu S, Tang S, Dong H, et al. Intense pulsed light for the treatment of Meibomian gland dysfunction: A systematic review and meta-analysis. Exp Ther Med. 2020; 20(2): 1815–1821.
  24. Lam PY, Shih KCo, Fong PY, et al. A Review on Evidence-Based Treatments for Meibomian Gland Dysfunction. Eye Contact Lens. 2020; 46(1): 3–16.
  25. Arita R, Mizoguchi T, Fukuoka S, et al. Multicenter Study of Intense Pulsed Light Therapy for Patients With Refractory Meibomian Gland Dysfunction. Cornea. 2018; 37(12): 1566–1571.
  26. Guilloto Caballero S, García Madrona JL, Colmenero Reina E. Effect of pulsed laser light in patients with dry eye syndrome. Arch Soc Esp Oftalmol. 2017; 92(11): 509–515.
  27. Yin Y, Liu N, Gong L, et al. Changes in the Meibomian Gland After Exposure to Intense Pulsed Light in Meibomian Gland Dysfunction (MGD) Patients. Curr Eye Res. 2018; 43(3): 308–313.
  28. Toyos R, Desai NR, Toyos M, et al. Intense pulsed light improves signs and symptoms of dry eye disease due to meibomian gland dysfunction: A randomized controlled study. PLoS One. 2022; 17(6): e0270268.
  29. Tashbayev B, Yazdani M, Arita R, et al. Intense pulsed light treatment in meibomian gland dysfunction: A concise review. Ocul Surf. 2020; 18(4): 583–594.
  30. Jones L, Downie LE, Korb D, et al. TFOS DEWS II Management and Therapy Report. Ocul Surf. 2017; 15(3): 575–628.

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