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commerciallyA novel cultivated oral mucosal epithelial cell sheet transplantation (COMET) method using a commercially available regenerative product sheet originating from human ectopic autologous tissue
, 2
Affiliations- Department of Ophthalmology, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan
- Department of Ophthalmology, Kawasaki Medical School, Kurashiki, Okayama, Japan
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Abstract
BACKGROUND: We report the first case of cultivated oral mucosal epithelial cell sheet transplantation (COMET) using a commercial product from a different human tissue.
CASE PRESENTATION: An 80-year-old man presented with bilateral blurred vision secondary to corneal limbal stem cell deficiency (LSCD) caused by bilateral ocular cicatricial pemphigoid (OCP). The patient first noted the loss of visual acuity in his left eye at 56 years of age. He was referred to a local hospital and was diagnosed with uveitis. He was administered ten bilateral ocular sub-tenon injections of triamcinolone acetonide. The uveitis progressed to cataracts, requiring bilateral phacoemulsification with intraocular lens implantation. Although the uveitis gradually improved, his visual acuity deteriorated due to the LSCD caused by OCP. At 61 years of age, amniotic membrane transplantation was performed in the left eye. However, its effect was limited, and OCP continued progressing in both eyes. On referral to our hospital, he had only light perception on visual acuity testing. The COMET was performed in the right eye using a commercially available product sheet (Oculal®; Japan Tissue Engineering Co., Ltd., Aichi, Japan). Ten days postoperatively, epithelialization was observed in the cornea and conjunctiva. His visual acuity improved to 20/1000. The patient was discharged on the same day.
CONCLUSION: This is the first report on the use of a commercially available ectopic product (Japan Tissue Engineering Co., Ltd., Aichi, Japan) originating from different human tissues (oral mucosa) for COMET. COMET may be a radical treatment for corneal LSCD.
Abstract
BACKGROUND: We report the first case of cultivated oral mucosal epithelial cell sheet transplantation (COMET) using a commercial product from a different human tissue.
CASE PRESENTATION: An 80-year-old man presented with bilateral blurred vision secondary to corneal limbal stem cell deficiency (LSCD) caused by bilateral ocular cicatricial pemphigoid (OCP). The patient first noted the loss of visual acuity in his left eye at 56 years of age. He was referred to a local hospital and was diagnosed with uveitis. He was administered ten bilateral ocular sub-tenon injections of triamcinolone acetonide. The uveitis progressed to cataracts, requiring bilateral phacoemulsification with intraocular lens implantation. Although the uveitis gradually improved, his visual acuity deteriorated due to the LSCD caused by OCP. At 61 years of age, amniotic membrane transplantation was performed in the left eye. However, its effect was limited, and OCP continued progressing in both eyes. On referral to our hospital, he had only light perception on visual acuity testing. The COMET was performed in the right eye using a commercially available product sheet (Oculal®; Japan Tissue Engineering Co., Ltd., Aichi, Japan). Ten days postoperatively, epithelialization was observed in the cornea and conjunctiva. His visual acuity improved to 20/1000. The patient was discharged on the same day.
CONCLUSION: This is the first report on the use of a commercially available ectopic product (Japan Tissue Engineering Co., Ltd., Aichi, Japan) originating from different human tissues (oral mucosa) for COMET. COMET may be a radical treatment for corneal LSCD.
Keywords
cultivated oral mucosal epithelial cell sheet transplantation (COMET), limbal stem cell deficiency (LSCD), ocular cicatricial pemphigoid (OCP), Oculal®, Japan Tissue Engineering Co., Ltd., Aichi, Japan
About this articleTitle
commerciallyA novel cultivated oral mucosal epithelial cell sheet transplantation (COMET) method using a commercially available regenerative product sheet originating from human ectopic autologous tissue
Journal
Issue
Vol 8 (2023): Continuous Publishing
Article type
Case report
Pages
126-130
Published online
2023-11-28
Page views
283
Article views/downloads
120
DOI
Bibliographic record
Ophthalmol J 2023;8:126-130.
Keywords
cultivated oral mucosal epithelial cell sheet transplantation (COMET)
limbal stem cell deficiency (LSCD)
ocular cicatricial pemphigoid (OCP)
Oculal®
Japan Tissue Engineering Co.
Ltd.
Aichi
Japan
Authors
Hisataka Fujimoto
Junichi Kiryu
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