Vol 6 (2021): Continuous Publishing
Case report
Published online: 2021-12-30

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Bilateral diffuse uveal melanocytic proliferation secondary to acute lymphoblastic leukemia: a case report

Muhanad Alshathly1, Mayada Abu Shanap1, Yacoub A. Yousef2, Mario Damiano Toro3, Reham Shehada1, Robert Rejdak3, Katarzyna Nowomiejska3, Iyad Sultan1, Mona Mohammad2
Ophthalmol J 2021;6:270-273.

Abstract

Background: Bilateral diffuse uveal melanocytic proliferation (BDUMP) is a very rare paraneoplastic syndrome that might present with carcinoma. We present a case of an atypical BDUMP secondary to acute B-cell lymphoblastic leukemia (ALL) and report management outcomes at six months follow-up.

Case presentation: A 14-year-old female patient with known B-cell ALL presented with blurred vision and headache. Ophthalmological examination revealed new-onset, multiple, round, and pigmented choroidal lesions. Based on the clinical presentation, the diagnosis of BDUMP was suspected. Screening for second malignancies was negative. After nine sessions of plasmapheresis, ophthalmologic examination showed stable, non-progressive retinal lesions with maintained vision and absence of retinal detachment or cataract.

Conclusion: This was a rare case of BDUMP in a young patient with a known case of ALL.

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