Vol 6 (2021): Continuous Publishing
Case report
Published online: 2021-12-30
Retinal nerve fiber layer defects in the presence of a physiological cup to disc ratio — a case series
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DOI: 10.5603/OJ.2021.0043
Ophthalmol J 2021;6:258-264.
Abstract
Retinal nerve fiber layer (RNFL) defects are one of the earliest signs of glaucoma. Typically, these RNFL defects are associated with an increased cup/disc ratio and a thinning of the neuroretinal rim. When the cup/disc ratio is within normal limits, the observer can misdiagnose subtle RNFL defects and lead to an essential delay in diagnosis, which has negative visual consequences in these patients. We present a case series report addressing RNFL defects with a physiological cup/disc ratio.
Keywords: glaucomaretinal nerve fiber defectscup/disc ratio
References
- Kwon YH, et al. Primary Open-Angle Glaucoma. N Engl J Med. 2009; 360(11): 1113–1124.
- Hood DC, Kardon RH. A framework for comparing structural and functional measures of glaucomatous damage. Prog Retin Eye Res. 2007; 26(6): 688–710.
- Inzelberg R, Ramirez JA, Nisipeanu P, et al. Retinal nerve fiber layer thinning in Parkinson disease. Vision Res. 2004; 44(24): 2793–2797.
- Paquet C, Boissonnot M, Roger F, et al. Abnormal retinal thickness in patients with mild cognitive impairment and Alzheimer's disease. Neurosci Lett. 2007; 420(2): 97–99.
- Hoyt WF, Schlicke B, Eckelhoff RJ. Fundoscopic appearance of a nerve-fibre-bundle defect. Br J Ophthalmol. 1972; 56(8): 577–583.
- Quigley HA. Examination of the retinal nerve fiber layer in the recognition of early glaucoma damage. Trans Am Ophthalmol Soc. 1986; 84: 920–966.
- Radius RL, Anderson DR. The histology of retinal nerve fiber layer bundles and bundle defects. Arch Ophthalmol. 1979; 97(5): 948–950.
- Airaksinen P, Drance S, Douglas G, et al. Diffuse and Localized Nerve Fiber Loss in Glaucoma. Am J Ophthalmol. 1984; 98(5): 566–571.
- Hoyt WF, Schlicke B, Eckelhoff RJ. Fundoscopic appearance of a nerve-fibre-bundle defect. Br J Ophthalmol. 1972; 56(8): 577–583.
- Tuulonen A, Lehtola J, Airaksinen P. Nerve Fiber Layer Defects with Normal Visual Fields. Ophthalmology. 1993; 100(5): 587–598.
- Jonas JB, Schiro D. Localized retinal nerve fiber layer defects in nonglaucomatous optic nerve atrophy. Graefes Arch Clin Exp Ophthalmol. 1994; 232(12): 759–760.
- Hwang YH, Kim YY, Kim HKi, et al. Ability of cirrus high-definition spectral-domain optical coherence tomography clock-hour, deviation, and thickness maps in detecting photographic retinal nerve fiber layer abnormalities. Ophthalmology. 2013; 120(7): 1380–1387.
- Foster PJ, Buhrmann R, Quigley HA, et al. The definition and classification of glaucoma in prevalence surveys. Br J Ophthalmol. 2002; 86(2): 238–242.