Assessment of retinal and optic disc vascular perfusion density in retinitis pigmentosa patients by optical coherence tomography angiography
Abstract
Background: The aim of the study was to evaluate the vascular flow density measured by optical coherence tomography angiography in patients with retinitis pigmentosa and to compare it with normal subjects. Material and methods: This was a cross-sectional case control study employing 16 eyes of eight patients with retinitis pigmentosa and 16 eyes of eight healthy subjects. Optical coherence tomography angiography was performed in all subjects. The macula was imaged with a 3 × 3 mm scan, whereas for the optic nerve head, a 4.5 × 4.5 mm scan was taken. Macular and optic disc vascular flow perfusion densities were measured. In addition, the FAZ area was calculated. All data were compared in the two groups. Results: The vascular flow perfusion density in the macular and in the optic nerve head was significantly lower in the retinitis pigmentosa group when compared with the control group. On the other hand, the foveal avascular zones area was not significantly different from controls. Conclusion: Patients with retinitis pigmentosa show a decreased macular and optic nerve head perfusion density compared with healthy subjects
Keywords: retinitis pigmentosaOCTAangiographyOCToptical coherence tomography
References
- Hartong DT, Berson EL, Dryja TP. Retinitis pigmentosa. Lancet. 2006; 368(9549): 1795–1809.
- Grunwald JE, Maguire AM, Dupont J. Retinal hemodynamics in retinitis pigmentosa. Am J Ophthalmol. 1996; 122(4): 502–508.
- Coscas GJ, Lupidi M, Coscas F, et al. Optical coherence tomography angiography versus traditional multi- modal imaging in assessing the activity of exudative age- related macular degeneration: a new diagnostic challenge. Retina. 2015; 35(11): 2219–2228.
- Battaglia Parodi M, Cicinelli MV, Rabiolo A, et al. Vessel density analysis in patients with retinitis pigmentosa by means of optical coherence tomography angiography. Br J Ophthalmol. 2017; 101(4): 428–432.
- Eysteinsson T, Hardarson SH, Bragason D, et al. Retinal vessel oxygen saturation and vessel diameter in retinitis pigmentosa. Acta Ophthalmol. 2014; 92(5): 449–453.
- Türksever C, Valmaggia C, Orgül S, et al. Retinal vessel oxygen saturation and its correlation with structural changes in retinitis pigmentosa. Acta Ophthalmol. 2014; 92(5): 454–460.
- Li ZY, Possin DE, Milam AH. Histopathology of bone spicule pigmentation in retinitis pigmentosa. Ophthalmology. 1995; 102(5): 805–816.
- Milam AH, Li ZY, Fariss RN. Histopathology of the human retina in retinitis pigmentosa. Prog Retin Eye Res. 1998; 17(2): 175–205.
- Sugahara M, Miyata M, Ishihara K, et al. Optical Coherence Tomography Angiography to Estimate Retinal Blood Flow in Eyes with Retinitis Pigmentosa. Sci Rep. 2017; 7: 46396.
- Miyata M, Oishi A, Hasegawa T, et al. Concentric Choriocapillaris Flow Deficits in Retinitis Pigmentosa Detected Using Wide-Angle Swept-Source Optical Coherence Tomography Angiography. Invest Ophthalmol Vis Sci. 2019; 60(4): 1044–1049.
- Takagi S, Hirami Y, Takahashi M, et al. Optical coherence tomography angiography in patients with retinitis pigmentosa who have normal visual acuity. Acta Ophthalmol. 2018; 96(5): e636–e642.
- Toto L, Borrelli E, Mastropasqua R, et al. Macular Features in Retinitis Pigmentosa: Correlations Among Ganglion Cell Complex Thickness, Capillary Density, and Macular Function. Invest Ophthalmol Vis Sci. 2016; 57(14): 6360–6366.
- Koyanagi Y, Murakami Y, Funatsu J, et al. Optical coherence tomography angiography of the macular microvasculature changes in retinitis pigmentosa. Acta Ophthalmol. 2018; 96(1): e59–e67.