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Jak skutecznie leczyć wysiękową postać zwyrodnienia plamki związanego z wiekiem według schematu PRN? Rola biomarkerów widocznych w obrazach optycznej koherentnej tomografii
Affiliations- Klinika Okulistyki Ogólnej, Uniwersytet Medyczny w Lublinie, Poland
open access
Abstract
Optymalizacja leczenia uwzględniająca indywidualny przebieg choroby nadal pozostaje jednym z podstawowych problemow w leczeniu wysiękowej postaci zwyrodnienia plamki związanego z wiekiem (AMD). W niniejszej pracy autorzy zawarli wskazowki, ktore mogą być pomocne podczas terapii według schematu pro-re-nata (PRN). Obecnie ma on zastosowanie u większości pacjentow będących w programie lekowym. Jednym z podstawowych problemow jest właściwa ocena aktywności choroby, ktora stanowi podstawę decyzji o wykonaniu kolejnej iniekcji lekow blokujących czynnik wzrostu środbłonka naczyń (anty-VEGF). Określenie parametrow, takich jak stan fotoreceptorow czy nabłonka barwnikowego siatkowki (RPE), lokalizacja płynu, zachowanie prawidłowego układu warstw siatkowki, obecność schorzeń pogranicza szklistkowo-siatkowkowego, wpływa na ocenę stanu klinicznego i rokowanie chorych.
Abstract
Optymalizacja leczenia uwzględniająca indywidualny przebieg choroby nadal pozostaje jednym z podstawowych problemow w leczeniu wysiękowej postaci zwyrodnienia plamki związanego z wiekiem (AMD). W niniejszej pracy autorzy zawarli wskazowki, ktore mogą być pomocne podczas terapii według schematu pro-re-nata (PRN). Obecnie ma on zastosowanie u większości pacjentow będących w programie lekowym. Jednym z podstawowych problemow jest właściwa ocena aktywności choroby, ktora stanowi podstawę decyzji o wykonaniu kolejnej iniekcji lekow blokujących czynnik wzrostu środbłonka naczyń (anty-VEGF). Określenie parametrow, takich jak stan fotoreceptorow czy nabłonka barwnikowego siatkowki (RPE), lokalizacja płynu, zachowanie prawidłowego układu warstw siatkowki, obecność schorzeń pogranicza szklistkowo-siatkowkowego, wpływa na ocenę stanu klinicznego i rokowanie chorych.
Keywords
zwyrodnienie plamki związane z wiekiem, aflibercept, ranibizumab, schemat PRN, biomarkery, optyczna koherentna tomografia
About this articleTitle
Jak skutecznie leczyć wysiękową postać zwyrodnienia plamki związanego z wiekiem według schematu PRN? Rola biomarkerów widocznych w obrazach optycznej koherentnej tomografii
Journal
Issue
Article type
Review paper
Pages
47-57
Published online
2017-11-13
Page views
838
Article views/downloads
4538
DOI
Bibliographic record
Ophthalmol J 2018;3(2):47-57.
Keywords
zwyrodnienie plamki związane z wiekiem
aflibercept
ranibizumab
schemat PRN
biomarkery
optyczna koherentna tomografia
Authors
Anna Matysik-Woźniak
Marek Rękas
Robert Rejdak
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