open access

Vol 1, No 2 (2016)
ORIGINAL PAPERS
Published online: 2016-07-07
Get Citation

Genetic association of apolipoprotein E with optic disc size

Anselm G.M. Jünemann, Udo Reulbach, Stefan Bleich, Johannes Kornhuber, Katarzyna Nowomiejska, Joanna Moneta-Wielgos, Robert Rejdak
DOI: 10.5603/OJ.2016.0010
·
Ophthalmol J 2016;1(2):59-61.

open access

Vol 1, No 2 (2016)
ORIGINAL PAPERS
Published online: 2016-07-07

Abstract

INTRODUCTION. The purpose of this clinical non-interventional cross-sectional study was to evaluate the role of apolipoprotein E (ApoE) gene alleles (e2, e3, e4) in the determination of optic disc size.

MATERIALS AND METHODS. In 32 normal controls, 54 patients with ocular hypertension (OHT), and 96 patients with primary open-angle the optic disc size was determined by planimetry using 15° colour stereo photographs. In all individuals ApoE genotyping was performed.

RESULTS. The size of the optic disc was significantly different between subjects with e3e2, e3e3, and e4e3 allele (Kruskal-Wallis-test, Chi-Square: 6.95, p = 0.031; 2.39, 2.77, and 2.78 mm2, respectively).

CONCLUSIONS. The results suggest that ApoE gene alleles are associated with optic disc size. ApoE may act as a modulator gene for optic disc morphogenesis.

Abstract

INTRODUCTION. The purpose of this clinical non-interventional cross-sectional study was to evaluate the role of apolipoprotein E (ApoE) gene alleles (e2, e3, e4) in the determination of optic disc size.

MATERIALS AND METHODS. In 32 normal controls, 54 patients with ocular hypertension (OHT), and 96 patients with primary open-angle the optic disc size was determined by planimetry using 15° colour stereo photographs. In all individuals ApoE genotyping was performed.

RESULTS. The size of the optic disc was significantly different between subjects with e3e2, e3e3, and e4e3 allele (Kruskal-Wallis-test, Chi-Square: 6.95, p = 0.031; 2.39, 2.77, and 2.78 mm2, respectively).

CONCLUSIONS. The results suggest that ApoE gene alleles are associated with optic disc size. ApoE may act as a modulator gene for optic disc morphogenesis.

Get Citation

Keywords

apolipoprotein E, optic disc size, ApoE gene alleles

About this article
Title

Genetic association of apolipoprotein E with optic disc size

Journal

Ophthalmology Journal

Issue

Vol 1, No 2 (2016)

Pages

59-61

Published online

2016-07-07

DOI

10.5603/OJ.2016.0010

Bibliographic record

Ophthalmol J 2016;1(2):59-61.

Keywords

apolipoprotein E
optic disc size
ApoE gene alleles

Authors

Anselm G.M. Jünemann
Udo Reulbach
Stefan Bleich
Johannes Kornhuber
Katarzyna Nowomiejska
Joanna Moneta-Wielgos
Robert Rejdak

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

VM Media sp. z o.o. VM Group sp.k., Grupa Via Medica, 73 Świętokrzyska St., 80–180 Gdańsk

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail: viamedica@viamedica.pl