open access

Vol 1, No 1 (2016)
REVIEW
Published online: 2016-03-30
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Drug bioavailability from topically applied ocular drops. Does drop size matter?

Anselm G.M. Jünemann, Tomasz Chorągiewicz, Małgorzata Ozimek, Paweł Grieb, Robert Rejdak
DOI: 10.5603/OJ.2016.0005
·
Ophthalmol J 2016;1(1):29-35.

open access

Vol 1, No 1 (2016)
REVIEW
Published online: 2016-03-30

Abstract

The application of drops containing ocular medicines to the conjunctival sac is the most common method of drug delivery to the anterior segment of the eye. Although this route of application seemingly displays numerous advantages, obtaining effective drug concentration at its site of action is challenging. The bioavailability of a topically applied drug depends on various factors related to the eye, to the drug and formulation, to the drop, and to the patient. The present article discusses their relative significance. From a drop applied to an eye, at most 5% of a drug dose enters the ocular structures. Of utmost importance for effective ocular drug delivery are patient compliance and the physicochemical properties of the drug. For a given concentration of an active substance, drop size may determine drug adverse effects but does not influence its efficacy.  

Abstract

The application of drops containing ocular medicines to the conjunctival sac is the most common method of drug delivery to the anterior segment of the eye. Although this route of application seemingly displays numerous advantages, obtaining effective drug concentration at its site of action is challenging. The bioavailability of a topically applied drug depends on various factors related to the eye, to the drug and formulation, to the drop, and to the patient. The present article discusses their relative significance. From a drop applied to an eye, at most 5% of a drug dose enters the ocular structures. Of utmost importance for effective ocular drug delivery are patient compliance and the physicochemical properties of the drug. For a given concentration of an active substance, drop size may determine drug adverse effects but does not influence its efficacy.  

Get Citation

Keywords

ocular drops, drug bioavailability, side effects, patient compliance

About this article
Title

Drug bioavailability from topically applied ocular drops. Does drop size matter?

Journal

Ophthalmology Journal

Issue

Vol 1, No 1 (2016)

Pages

29-35

Published online

2016-03-30

DOI

10.5603/OJ.2016.0005

Bibliographic record

Ophthalmol J 2016;1(1):29-35.

Keywords

ocular drops
drug bioavailability
side effects
patient compliance

Authors

Anselm G.M. Jünemann
Tomasz Chorągiewicz
Małgorzata Ozimek
Paweł Grieb
Robert Rejdak

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