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Vol 1, No 1 (2016)
ORIGINAL PAPERS
Published online: 2016-03-30
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25 Hz adaptation: Influence on recovery time in glaucoma

Katharina Brehmer, Pia Rutrecht, Simon Mißlinger, Anselm Jünemann, Folkert Horn, Jan Kremers, Bettina Hohberger
DOI: 10.5603/OJ.2016.0001
·
Ophthalmol J 2016;1(1):1-9.

open access

Vol 1, No 1 (2016)
ORIGINAL PAPERS
Published online: 2016-03-30

Abstract

INTRODUCTION. Normal temporal contrast sensitivity is maximally influenced by pre-adaptation with 25-Hz temporal contrast flicker. The aim of this study was to investigate the effects of 25-Hz contrast adaptation on recovery of contrast sensitivity in normals, patients with ocular hypertension, preperimetric, perimetric and advanced perimetric open-angle glaucoma.

MATERIALS AND METHODS. Temporal contrast sensitivity was examined after pre-adaptation with 25 Hz in the following: 43 normals, 14 ocular hypertension, 10 preperimetric primary open-angle glaucoma, and 33 perimetric open-an­gle glaucoma patients. After pre-adaptation (the time after which a test stimulus could be detected again), recovery time (RT) was measured at 3% and 5% test contrast. Additionally, 25 patients with advanced perimetric open-angle glaucoma were measured at 12%, 25%, and 35% contrast and compared to a normal group consisting of 15 subjects.

RESULTS. 1. Measurements of RT are reliable (Cronbach’s a > 0.8). 2. RT was age-dependent requiring an age-correction in further analyses. 3. RT3% and RT5% were significantly prolonged in perimetric primary open-angle glau­coma compared to normals (3% test contrast: p = 0.007; 5% test contrast: p = 0.035). 4. Within each group, RT3% and RT5% were significantly different at both test contrasts (normals, perimetric open-angle glaucoma: p < 0.001; ocular hypertension: p = 0.007; preperimetric open-angle glaucoma: p = 0.035). 5. RT3% and RT5% were significantly correlated with mean defect (p < 0.001) and retinal nerve fibre layer thickness (p = 0.018). RT5% was correlated with loss variance (p = 0.048). 6. RT12%, RT25% and RT35% were significantly prolonged in advanced perimetric glaucoma (p < 0.001), and correlated with mean defect (p < 0.001, p = 0.002, p = 0.013) and retinal nerve fibre layer thickness (p < 0.001, p = 0.003, p = 0.013). RT12% was also correlated with loss variance (p = 0.016).

CONCLUSIONS. Measurements of RT after 25-Hz pre-adaptation can be used in glaucoma diagnosis and follow-up examination, especially in monitoring glaucoma progress in advanced perimetric primary open-angle glaucoma.

Abstract

INTRODUCTION. Normal temporal contrast sensitivity is maximally influenced by pre-adaptation with 25-Hz temporal contrast flicker. The aim of this study was to investigate the effects of 25-Hz contrast adaptation on recovery of contrast sensitivity in normals, patients with ocular hypertension, preperimetric, perimetric and advanced perimetric open-angle glaucoma.

MATERIALS AND METHODS. Temporal contrast sensitivity was examined after pre-adaptation with 25 Hz in the following: 43 normals, 14 ocular hypertension, 10 preperimetric primary open-angle glaucoma, and 33 perimetric open-an­gle glaucoma patients. After pre-adaptation (the time after which a test stimulus could be detected again), recovery time (RT) was measured at 3% and 5% test contrast. Additionally, 25 patients with advanced perimetric open-angle glaucoma were measured at 12%, 25%, and 35% contrast and compared to a normal group consisting of 15 subjects.

RESULTS. 1. Measurements of RT are reliable (Cronbach’s a > 0.8). 2. RT was age-dependent requiring an age-correction in further analyses. 3. RT3% and RT5% were significantly prolonged in perimetric primary open-angle glau­coma compared to normals (3% test contrast: p = 0.007; 5% test contrast: p = 0.035). 4. Within each group, RT3% and RT5% were significantly different at both test contrasts (normals, perimetric open-angle glaucoma: p < 0.001; ocular hypertension: p = 0.007; preperimetric open-angle glaucoma: p = 0.035). 5. RT3% and RT5% were significantly correlated with mean defect (p < 0.001) and retinal nerve fibre layer thickness (p = 0.018). RT5% was correlated with loss variance (p = 0.048). 6. RT12%, RT25% and RT35% were significantly prolonged in advanced perimetric glaucoma (p < 0.001), and correlated with mean defect (p < 0.001, p = 0.002, p = 0.013) and retinal nerve fibre layer thickness (p < 0.001, p = 0.003, p = 0.013). RT12% was also correlated with loss variance (p = 0.016).

CONCLUSIONS. Measurements of RT after 25-Hz pre-adaptation can be used in glaucoma diagnosis and follow-up examination, especially in monitoring glaucoma progress in advanced perimetric primary open-angle glaucoma.

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Keywords

glaucoma, ocular hypertension, flicker adaptation, recovery time, temporal contrast sensitivity, advanced glaucoma

About this article
Title

25 Hz adaptation: Influence on recovery time in glaucoma

Journal

Ophthalmology Journal

Issue

Vol 1, No 1 (2016)

Pages

1-9

Published online

2016-03-30

DOI

10.5603/OJ.2016.0001

Bibliographic record

Ophthalmol J 2016;1(1):1-9.

Keywords

glaucoma
ocular hypertension
flicker adaptation
recovery time
temporal contrast sensitivity
advanced glaucoma

Authors

Katharina Brehmer
Pia Rutrecht
Simon Mißlinger
Anselm Jünemann
Folkert Horn
Jan Kremers
Bettina Hohberger

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