Tom 7, Nr 5 (2021)
Artykuł przeglądowy
Opublikowany online: 2021-11-25
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3063
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Kliniczne prognostyczne i predykcyjne czynniki kwalifikacji do immunoterapii
Onkol Prakt Klin Edu 2021;7(5):301-306.
Streszczenie
Kwalifikacja chorych do immunoterapii opiera się na wskazaniach rejestracyjnych leków z uwzględnieniem zapisów programów lekowych. Obserwacje z codziennej praktyki pozwalają wskazać dodatkowe czynniki rokownicze i predykcyjne w odniesieniu do immunoterapii. Najbardziej istotnymi elementami negatywnie wpływającymi na skuteczność immunoterapii są: gorszy stan sprawności, lokalizacja zmian wtórnych w wątrobie i mózgowiu, znaczne zaawansowanie zmian, nieprawidłowości w badaniach laboratoryjnych i brak korzyści klinicznej z wcześniej prowadzonego leczenia systemowego . Ponadto obserwuje się brak skuteczności immunoterapii wśród chorych z zaburzeniami molekularnymi (w szczególności w genach EGFR, ALK).
Słowa kluczowe: immunoterapiaczynniki prognostyczneczynniki predykcyjneniedrobnokomórkowy rak płuca
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