Tom 7, Nr 6 (2021)
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Opublikowany online: 2021-06-16

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Eksport do Mediów Społecznościowych

Eksport do Mediów Społecznościowych

Leczenie podtrzymujące awelumabem u chorych na uogólnionego raka urotelialnego

Jakub Kucharz1
Onkol Prakt Klin Edu 2021;7(6):409-413.

Streszczenie

Wyniki leczenia chorych z rozpoznaniem uogólnionego raka urotelialnego pozostają niezadowalające. Mimo stosunkowo wysokiego odsetka odpowiedzi na chemioterapię opartą na pochodnych platyny mediana czasu przeżycia całkowitego w tej grupie chorych wynosi około 14 miesięcy. Immunoterapia z wykorzystaniem przeciwciał anty-PD-1/anty-PD-L1 w drugiej linii leczenia wykazuje istotną aktywność, jednak ze względu na zły stan sprawności blisko 50% chorych nie kwalifikuje się do dalszego leczenia przyczynowego. W związku z tym konieczne jest poszukiwanie nowych strategii terapeutycznych. W badaniu III fazy JAVELIN Bladder 100 wykazano, że zastosowanie awelumabu w leczeniu podtrzymującym po uzyskaniu kontroli choroby poprzez chemioterapię pierwszej linii opartą na pochodnych platyny pozwala na wydłużenie czasu przeżycia całkowitego oraz czasu wolnego od progresji przy dobrym profilu bezpieczeństwa.

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