Tom 7, Nr 6 (2021)
Artykuł przeglądowy
Opublikowany online: 2021-06-16
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Leczenie podtrzymujące awelumabem u chorych na uogólnionego raka urotelialnego
Onkol Prakt Klin Edu 2021;7(6):409-413.
Streszczenie
Wyniki leczenia chorych z rozpoznaniem uogólnionego raka urotelialnego pozostają niezadowalające. Mimo stosunkowo wysokiego odsetka odpowiedzi na chemioterapię opartą na pochodnych platyny mediana czasu przeżycia całkowitego w tej grupie chorych wynosi około 14 miesięcy. Immunoterapia z wykorzystaniem przeciwciał anty-PD-1/anty-PD-L1 w drugiej linii leczenia wykazuje istotną aktywność, jednak ze względu na zły stan sprawności blisko 50% chorych nie kwalifikuje się do dalszego leczenia przyczynowego. W związku z tym konieczne jest poszukiwanie nowych strategii terapeutycznych. W badaniu III fazy JAVELIN Bladder 100 wykazano, że zastosowanie awelumabu w leczeniu podtrzymującym po uzyskaniu kontroli choroby poprzez chemioterapię pierwszej linii opartą na pochodnych platyny pozwala na wydłużenie czasu przeżycia całkowitego oraz czasu wolnego od progresji przy dobrym profilu bezpieczeństwa.
Słowa kluczowe: rak urotelialnyleczenie podtrzymująceawelumabimmunoterapia
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