open access

Vol 10, No 1 (2014)
Case report
Published online: 2014-03-06
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Cardiotoxicity of fluoropyrimidine derivatives as a factor limiting the effectiveness of treatment

Marek Gełej, Kazimierz Drosik
Onkol. Prak. Klin 2014;10(1):32-37.

open access

Vol 10, No 1 (2014)
CASE REPORTS
Published online: 2014-03-06

Abstract

5-fluorouracil and capecitabine are cytostatics of critical importance in the strategy of systemic therapy for colorectal cancer. Cardiotoxicity associated with these drugs is a documented adverse event. The mechanism causing cardiac side effects is poorly understood. In the course of administration of fluoropyrimidines the patients may suffer from, among other things, coronary vasospasm. In this paper we present the case of a rectal cancer patient who experienced symptoms of acute coronary syndrome during her treatment with 5-fluorouracil. Cardiotoxic symptoms also appeared during attempted prophylactic use of vasodilators and after the replacement of the chemotherapeutic agent with the oral fluoropyrimidine derivative capecitabine. Occurrence of cardiac side effects may cause large diagnostic and therapeutic difficulties and be the reason of treatment failure. What is needed is an algorithm to deal with such cases, based on the best available scientific evidence.

Abstract

5-fluorouracil and capecitabine are cytostatics of critical importance in the strategy of systemic therapy for colorectal cancer. Cardiotoxicity associated with these drugs is a documented adverse event. The mechanism causing cardiac side effects is poorly understood. In the course of administration of fluoropyrimidines the patients may suffer from, among other things, coronary vasospasm. In this paper we present the case of a rectal cancer patient who experienced symptoms of acute coronary syndrome during her treatment with 5-fluorouracil. Cardiotoxic symptoms also appeared during attempted prophylactic use of vasodilators and after the replacement of the chemotherapeutic agent with the oral fluoropyrimidine derivative capecitabine. Occurrence of cardiac side effects may cause large diagnostic and therapeutic difficulties and be the reason of treatment failure. What is needed is an algorithm to deal with such cases, based on the best available scientific evidence.
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Keywords

cardiotoxicity, 5-fluorouracil, capecitabine, colorectal cancer

About this article
Title

Cardiotoxicity of fluoropyrimidine derivatives as a factor limiting the effectiveness of treatment

Journal

Oncology in Clinical Practice

Issue

Vol 10, No 1 (2014)

Article type

Case report

Pages

32-37

Published online

2014-03-06

Bibliographic record

Onkol. Prak. Klin 2014;10(1):32-37.

Keywords

cardiotoxicity
5-fluorouracil
capecitabine
colorectal cancer

Authors

Marek Gełej
Kazimierz Drosik

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