open access

Vol 5, No 2 (2002)
Short communications
Published online: 2002-06-07
Submitted: 2012-01-23
Get Citation

Effect of biventricular pacing on heart function evaluated by gated blood pool study in patients with end-stage heart failure

Witold Cholewiński, Anna Tarkowska, Andrzej Kutarski, Bogusław Stefaniak, Ewa Poniatowicz-Frasunek, Krzysztof Oleszczak
Nucl. Med. Rev 2002;5(2):155-157.

open access

Vol 5, No 2 (2002)
Short communications
Published online: 2002-06-07
Submitted: 2012-01-23

Abstract

BACKGROUND: Biventricular cardiac pacing has been used as a complementary form of therapy in patients with severe heart failure. The aim of this study was to evaluate the effect of the synchronous stimulation of both ventricles on the heart function measured by gated blood pool study (GBP).
MATERIAL AND METHODS:Ten patients (9 men and 1 woman aged 53–74 years) with end-stage heart failure (HF) were studied. In all patients long-term biventricular pacing (BV) was applied. The obtained results were compared with single-chamber stimulation in 5 patients and with sinus rhythm (SR) in 8 patients. All patients underwent repeated GBP with RBC labelled with 740 MBq of 99 mTc-pertechnetate. The LVEF was calculated according to the standard method based on the count rates. Phase analysis was performed with the standard method using first Fourier element.
RESULTS: Clinically in almost all patients moderate to important symptomatic improvement has been observed. The analysis of LVEF values revealed that BV pacing resulted in significantly higher values only in comparison with SR (21.6% ± 10.3 v. 20.1% ± 10.1; p < 0.05). The phase shift between both ventriclesventricles by BV pacing was positive and similar to that obtained with SR and RV stimulation (14.0° ± 29.6 v. 13.4° ± 37.6 and 7.4° ± 26.5 v. 6.0° ± 17.1 respectively). However, in comparison with LV pacing, BV stimulation revealed a change of dominant conduction abnormalities with a delay of RV contraction in relation to LV (9.0° ± 17.5 v. –3.0° ± 11.4).
CONCLUSIONS: Biventricular pacing results in slight improvement of LVEF in patients with heart failure and can be considered a promising approach in patients with end-stage heart failure. Synchronous stimulation of both ventricles not always results in decrease of interventricular shift, however that observation requires further studies on a larger population.

Abstract

BACKGROUND: Biventricular cardiac pacing has been used as a complementary form of therapy in patients with severe heart failure. The aim of this study was to evaluate the effect of the synchronous stimulation of both ventricles on the heart function measured by gated blood pool study (GBP).
MATERIAL AND METHODS:Ten patients (9 men and 1 woman aged 53–74 years) with end-stage heart failure (HF) were studied. In all patients long-term biventricular pacing (BV) was applied. The obtained results were compared with single-chamber stimulation in 5 patients and with sinus rhythm (SR) in 8 patients. All patients underwent repeated GBP with RBC labelled with 740 MBq of 99 mTc-pertechnetate. The LVEF was calculated according to the standard method based on the count rates. Phase analysis was performed with the standard method using first Fourier element.
RESULTS: Clinically in almost all patients moderate to important symptomatic improvement has been observed. The analysis of LVEF values revealed that BV pacing resulted in significantly higher values only in comparison with SR (21.6% ± 10.3 v. 20.1% ± 10.1; p < 0.05). The phase shift between both ventriclesventricles by BV pacing was positive and similar to that obtained with SR and RV stimulation (14.0° ± 29.6 v. 13.4° ± 37.6 and 7.4° ± 26.5 v. 6.0° ± 17.1 respectively). However, in comparison with LV pacing, BV stimulation revealed a change of dominant conduction abnormalities with a delay of RV contraction in relation to LV (9.0° ± 17.5 v. –3.0° ± 11.4).
CONCLUSIONS: Biventricular pacing results in slight improvement of LVEF in patients with heart failure and can be considered a promising approach in patients with end-stage heart failure. Synchronous stimulation of both ventricles not always results in decrease of interventricular shift, however that observation requires further studies on a larger population.
Get Citation

Keywords

biventricular pacing; gated blood pool; LVEF

About this article
Title

Effect of biventricular pacing on heart function evaluated by gated blood pool study in patients with end-stage heart failure

Journal

Nuclear Medicine Review

Issue

Vol 5, No 2 (2002)

Pages

155-157

Published online

2002-06-07

Bibliographic record

Nucl. Med. Rev 2002;5(2):155-157.

Keywords

biventricular pacing
gated blood pool
LVEF

Authors

Witold Cholewiński
Anna Tarkowska
Andrzej Kutarski
Bogusław Stefaniak
Ewa Poniatowicz-Frasunek
Krzysztof Oleszczak

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By "Via Medica sp. z o.o." sp.k., Świętokrzyska 73 street, 80–180 Gdańsk, Poland

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail: viamedica@viamedica.pl