open access

Vol 5, No 2 (2002)
Published online: 2002-06-07
Submitted: 2012-01-23
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111In-platelets dynamic study in chronic immune thrombocytopenic purpura

Mila V. Todorović-Tirnanić, Vladimir B. Obradovic, Smiljana V. Pavlović, Nada D. Suvajdžić, Ivo V. Elezović, Milica D. Colović, Vladimir B. Bošnjaković
Nucl. Med. Rev 2002;5(2):121-125.

open access

Vol 5, No 2 (2002)
Published online: 2002-06-07
Submitted: 2012-01-23

Abstract

BACKGROUND: The aim of this work was to estimate the significance of a dynamic study performed during the first 20 minutes after autologous 111In-oxinate-platelets injection in patients with chronic immune thrombocytopenic purpura (ITP). Two hypotheses were tested: a) dynamic study indicates the place of platelet sequestration; b) dynamic study reflects the quality of platelet separation and labelling procedure.
MATERIAL AND METHODS: Thirty-nine persons were investigated: 25 with shortened platelet life span (ITP), and 14 with normal platelet life span (6 healthy subjects and eight patients with myelodysplastic syndrome - MDS). Platelet blood count on the day of platelet labelling, general yield of platelet labelling (GYL), differential yield of platelet labelling (DYL), platelet life span, dynamic study with initial platelet accumulation in the liver (IPAL), sequential static study for determining the platelet sequestration index (SI) and platelet sequestration site (SS) were investigated.
RESULTS: Two types of labelled platelet kinetics were determined in both groups of patients: IPAL < 20% and IPAL > 20%. A statistically significant difference in GYL and DYL was noted between the patients with IPAL < 20% and IPAL > 20%. No significant difference was registered in platelet blood count, life span, SS and SI between the two groups of patients. Both yields of platelet labelling were higher in the group with IPAL < 20%. There was no correlation between IPAL and platelet SI, or between IPAL and platelet SS.
CONCLUSIONS: Dynamic study with 111In-platelets cannot predict platelet sequestration site in ITP patients, but it is a useful and sensitive method of platelet labelling procedure quality control.

Abstract

BACKGROUND: The aim of this work was to estimate the significance of a dynamic study performed during the first 20 minutes after autologous 111In-oxinate-platelets injection in patients with chronic immune thrombocytopenic purpura (ITP). Two hypotheses were tested: a) dynamic study indicates the place of platelet sequestration; b) dynamic study reflects the quality of platelet separation and labelling procedure.
MATERIAL AND METHODS: Thirty-nine persons were investigated: 25 with shortened platelet life span (ITP), and 14 with normal platelet life span (6 healthy subjects and eight patients with myelodysplastic syndrome - MDS). Platelet blood count on the day of platelet labelling, general yield of platelet labelling (GYL), differential yield of platelet labelling (DYL), platelet life span, dynamic study with initial platelet accumulation in the liver (IPAL), sequential static study for determining the platelet sequestration index (SI) and platelet sequestration site (SS) were investigated.
RESULTS: Two types of labelled platelet kinetics were determined in both groups of patients: IPAL < 20% and IPAL > 20%. A statistically significant difference in GYL and DYL was noted between the patients with IPAL < 20% and IPAL > 20%. No significant difference was registered in platelet blood count, life span, SS and SI between the two groups of patients. Both yields of platelet labelling were higher in the group with IPAL < 20%. There was no correlation between IPAL and platelet SI, or between IPAL and platelet SS.
CONCLUSIONS: Dynamic study with 111In-platelets cannot predict platelet sequestration site in ITP patients, but it is a useful and sensitive method of platelet labelling procedure quality control.
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Keywords

labelled platelets; 111In-oxinate; platelet kineticontrol of labelled cellscs; chronic immune thrombocytopenic purpura (ITP); quality of labelled cells

About this article
Title

111In-platelets dynamic study in chronic immune thrombocytopenic purpura

Journal

Nuclear Medicine Review

Issue

Vol 5, No 2 (2002)

Pages

121-125

Published online

2002-06-07

Bibliographic record

Nucl. Med. Rev 2002;5(2):121-125.

Keywords

labelled platelets
111In-oxinate
platelet kineticontrol of labelled cellscs
chronic immune thrombocytopenic purpura (ITP)
quality of labelled cells

Authors

Mila V. Todorović-Tirnanić
Vladimir B. Obradovic
Smiljana V. Pavlović
Nada D. Suvajdžić
Ivo V. Elezović
Milica D. Colović
Vladimir B. Bošnjaković

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