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Preliminary studies with 188Rhenium-tin colloid for radiation synovectomy: preparation, size determination, in-vivo distribution, effect and dosimetry studies
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Abstract
MATERIAL AND METHODS: We prepared a 188Re-tin colloid in a reaction carried out either at 100°C or at room temperature (RT). The size of the colloid particles was measured with a laser lightscattering method, and their biodistribution, dosimetric aspects and therapeutic effects were studied in an antigen-induced arthritis (AIA) model in rabbits. 188Re-tin colloid solution was injected intra-articularly into the knee joints of rabbits with AIA and imaging studies were performed. Blood samples were collected post injection for estimation of the blood residence time. We also injected 2 intact rabbits in the same manner with 188Re perrhenate solution in order to observe its effects and distribution in the body. All the treated rabbit knees were subjected to histopathology.
RESULTS: The colloid particle size distribution was different after preparation at the different reaction temperatures, with a more suitable mean of 4.53 µm in the RT preparation. The dose delivered to the synovial surface was between 3.51 and 4.21 Gy and that to the bone surface was between 0.70 and 0.84 Gy. Histopathologic examination revealed the development of fibrous connective tissue in the AIA knees 4 weeks after treatment, but not in the control group.
CONCLUSIONS: The 188Re-tin colloid preparation used in this study was suitable for radiation synovectomy application. It requires modifications in the preparation protocol so as to increase the labeling efficiency in correlation with an appropriate particle size.
Abstract
MATERIAL AND METHODS: We prepared a 188Re-tin colloid in a reaction carried out either at 100°C or at room temperature (RT). The size of the colloid particles was measured with a laser lightscattering method, and their biodistribution, dosimetric aspects and therapeutic effects were studied in an antigen-induced arthritis (AIA) model in rabbits. 188Re-tin colloid solution was injected intra-articularly into the knee joints of rabbits with AIA and imaging studies were performed. Blood samples were collected post injection for estimation of the blood residence time. We also injected 2 intact rabbits in the same manner with 188Re perrhenate solution in order to observe its effects and distribution in the body. All the treated rabbit knees were subjected to histopathology.
RESULTS: The colloid particle size distribution was different after preparation at the different reaction temperatures, with a more suitable mean of 4.53 µm in the RT preparation. The dose delivered to the synovial surface was between 3.51 and 4.21 Gy and that to the bone surface was between 0.70 and 0.84 Gy. Histopathologic examination revealed the development of fibrous connective tissue in the AIA knees 4 weeks after treatment, but not in the control group.
CONCLUSIONS: The 188Re-tin colloid preparation used in this study was suitable for radiation synovectomy application. It requires modifications in the preparation protocol so as to increase the labeling efficiency in correlation with an appropriate particle size.
Keywords
radiosynovectomy; antigen-induced arthritis; rheumatoid arthritis; dosimetry; radiocolloid; radiopharmaceutical
About this articleTitle
Preliminary studies with 188Rhenium-tin colloid for radiation synovectomy: preparation, size determination, in-vivo distribution, effect and dosimetry studies
Journal
Issue
Pages
99-104
Published online
2002-06-07
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539
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Bibliographic record
Nucl. Med. Rev 2002;5(2):99-104.
Keywords
radiosynovectomy
antigen-induced arthritis
rheumatoid arthritis
dosimetry
radiocolloid
radiopharmaceutical
Authors
Domokos Máthé
Pradip R. Chaudhari
Lajos Balogh
András Polyák
Réka Király
Gábor Andocs
Edina Perge
Róbert Glávits
Gyōzō A. Jánoki
