open access
Estimation of usefulness of monitoring tissue polypeptide antigen - TPA-M concentrations in the effectiveness surgical treatment of urinary bladder cancer
open access
Abstract
MATERIAL AND METHODS: The research included 98 patients, all of whom had undertaken electroresection of urinary bladder tumour (TURT), which enabled its removal, and then estimation of malignancy and progression stage according to the international TNM scale. The mean age was 62.7 years. All patients had blood samples taken to determine TPA-M and then underwent routine cystoscopy examination.
RESULTS: The patients with tumour recurrence (60, mean age 64 ± 10) had TPA 30.2 ± 4.3 U/l, the patients without recurrence (38, mean age 61.3 ± 11) had TPA-M 26.2 ± 3.18 U/l (p > 0.1). Taking the TPA-M threshold point 85 U/l as normal, true-positive results were 16.3%, true-negative were 31.6%, falsepositive results were 7.1% and false-negative were 44.9%. The ROC curves with the calculated area under them are the measurement of the diagnostic estimation of TPA-M concentrations in specificity and sensitivity categories.
CONCLUSIONS: For the examined group the calculated P was 0.45. If P value is under 0.5 it is considered that the test should not be used in diagnosing recurrence of urinary bladder cancer.
Abstract
MATERIAL AND METHODS: The research included 98 patients, all of whom had undertaken electroresection of urinary bladder tumour (TURT), which enabled its removal, and then estimation of malignancy and progression stage according to the international TNM scale. The mean age was 62.7 years. All patients had blood samples taken to determine TPA-M and then underwent routine cystoscopy examination.
RESULTS: The patients with tumour recurrence (60, mean age 64 ± 10) had TPA 30.2 ± 4.3 U/l, the patients without recurrence (38, mean age 61.3 ± 11) had TPA-M 26.2 ± 3.18 U/l (p > 0.1). Taking the TPA-M threshold point 85 U/l as normal, true-positive results were 16.3%, true-negative were 31.6%, falsepositive results were 7.1% and false-negative were 44.9%. The ROC curves with the calculated area under them are the measurement of the diagnostic estimation of TPA-M concentrations in specificity and sensitivity categories.
CONCLUSIONS: For the examined group the calculated P was 0.45. If P value is under 0.5 it is considered that the test should not be used in diagnosing recurrence of urinary bladder cancer.
Keywords
TPA-M; monitoring; urinary bladder cancer
Title
Estimation of usefulness of monitoring tissue polypeptide antigen - TPA-M concentrations in the effectiveness surgical treatment of urinary bladder cancer
Journal
Issue
Article type
Research paper
Pages
109-111
Published online
2002-06-07
Page views
745
Article views/downloads
1225
Bibliographic record
Nucl. Med. Rev 2002;5(2):109-111.
Keywords
TPA-M
monitoring
urinary bladder cancer
Authors
Aleksandra Kochańska-Dziurowicz
Michał J. Mielniczuk
Aleksandra Bijak
Ryszard Palugniok